GPCR/G protein(G 蛋白偶联受体/G 蛋白)

Cat.No. 产品名称 Information

GC35338 Anamorelin hydrochloride

阿拉莫林盐酸盐,RC-1291 hydrochloride; ONO-7643 hydrochloride

A small molecule agonist of GHS-R1a

GC35337 Anamorelin Fumarate

富马酸阿拉莫林; ONO-7643 Fumarate; RC1291 Fumarate

A small molecule agonist of GHS-R1a

GC35314 AMG 837 sodium salt An FFAR1 (GPR40) partial

GC35313 AMG 837 calcium hydrate An FFAR1 (GPR40) partial

GC35303 Alosetron D3 Hydrochloride

GR-68755C D3

Alosetron D3 Hydrochloride (GR-68755C D3) 是Alosetron氘代化合物标准品。

GC35302 Alosetron (Hydrochloride(1:X))

盐酸阿洛司琼,GR 68755 (Hydrochloride(1

A 5-HT₃ receptor antagonist

GC35301 Alosetron ((Z)-2-butenedioate)

马来酸阿洛司琼; GR 68755 ((Z)-2-butenedioate); GR 68755X ((Z)-2-butenedioate)

Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) 是5-HT3受体拮抗剂，可作用于肠易激综合征。

GC35282 Alexamorelin Met 1

Alexamorelin Met 1 是alexamorelin的代谢产物。七肽Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2（Alexamorelin）是在体外试验中抑制生长激素促分泌素结合的合成分子。

GC35272 Ajmalicine

萝巴新,Raubasine

A terpenoid indole alkaloid

GC35270 Agomelatine L(+)-Tartaric acid

阿戈美拉汀 L(+)-酒石酸; S-20098 L(+)-Tartaric acid

Agomelatine（L(+)-酒石酸）可抗抑郁，是一种去甲肾上腺素-多巴胺抑制解除剂（NDDI），能拮抗5-HT2C受体。

GC35269 Agomelatine hydrochloride

维度新; S-20098 hydrochloride

A melatonin receptor agonist and 5-HT_2B and 5-HT_2C antagonist

GC35255 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA

ACTH (1-39) (mouse, rat) TFA

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) 是一种有效的黑皮质素 2 型受体 (melanocortin 2 receptor, MC2) 激动剂。

GC35254 Adrenocorticotropic Hormone (ACTH) (1-39), rat

ACTH (1-39) (mouse, rat)

Adrenocorticotropic Hormone (ACTH) (1-39), rat 是一种有效的黑皮质素 2 型受体 (melanocortin 2 receptor, MC2) 激动剂。

GC35252 Adoprazine

阿哆嗪; SLV313

Adoprazine是5-HT1A受体的完全激动剂和D2/3受体的拮抗剂。

GC35251 AdipoRon hydrochloride An adiponectin receptor agonist

GC35250 Adenosine deaminase

腺苷脫氨酶

腺苷脱氨酶（Adenosine deaminase，ADA）是参与嘌呤代谢途径的关键酶，对腺苷和脱氧腺苷具有不可逆脱氨作用，分别转化为肌苷和脱氧肌苷。

GC35249 Adenosine antagonist-1 Adenosine antagonist-1 是一个腺苷 A3 受体 (AA3R) 拮抗剂。

GC35248 Adenosine 5'-monophosphate monohydrate

腺苷-5'-单磷酸一水合物,5'-AMP monohydrate

Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).

GC35244 ACTH (1-17) TFA

α1-17-ACTH TFA

ACTH (1-17) TFA 是促肾上腺皮质激素类似物，是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂，Ki 值为 0.21 nM。

GC35243 ACTH (1-14) TFA

Adrenocorticotropic Hormone Fragment 1-14 TFA

ACTH (1-14) (TFA) 是促肾上腺皮质激素的多肽片段，后者能够促进皮质醇的释放。

GC35185 7,4'-Dihydroxyflavone

7,4'-二羟基黄酮

7,4'-Dihydroxyflavone是一种从甘草（Glycyrrhiza uralensis）中分离得到的口服活性黄酮类化合物，可作为嗜酸性粒细胞趋化因子/CCL11和羰基还原酶1（CBR1）的抑制剂。

GC35168 5-O-Demethylnobiletin

去甲基川陈皮素,5-Demethylnobiletin

A flavonoid with diverse biological activities

GC35027 [Sar9] Substance P [Sar9] Substance P 是一种有效的选择性神经激肽 (NK)-1 受体激动剂。

GC35025 [Sar1, Ile8]-Angiotensin II [Sar1, Ile8]-Angiotensin II 是一种多肽，在血管平滑肌细胞中有多种作用，包括正常动脉的收缩，培养的细胞或病变血管的肥大或增生等。

GC35019 [Nle11]-Substance P [Nle11]-Substance P 是物质 P 类似物，避免了甲硫氨酸氧化问题。

GC35015 [Des-Arg9]-Bradykinin

[Des-Arg9]-缓激肽

An active metabolite of bradykinin and agonist of bradykinin B₁ receptors

GC35011 (Z)-Thiothixene

替沃噻吨

(Z)-Thiothixene 是 serotonergic receptor 的拮抗剂，来自专利 US 20150141345 A1。

GC35002 (S)-Mapracorat

(S)-ZK-245186; (S)-BOL-303242X

(S)-Mapracorat 是一种选择性且活性较小的糖皮质激素受体激动剂。

GC34995 (R,R)-Palonosetron Hydrochloride

(R,R)-盐酸帕洛诺司琼

(R,R)-Palonosetron Hydrochloride 是一个有活性的 Palonosetron 对映异构体。

GC34985 (R)-ADX-47273 (R)-ADX-47273 是一个有效的，mGluR5 的正性变构调节剂，其增强效应的 EC50 值为 168 nM。

GC34965 (20S)-Protopanaxatriol

20 (S)-原人参三醇; 20(S)-APPT; g-PPT

(20S)-Protopanaxatriol是一种来源于人参皂苷的代谢产物，具有多种生物活性和药理作用。

GC34963 (1R,2S)-VU0155041 (1R,2S)-VU0155041是VU0155041的顺式异构体。(1R,2S)-VU0155041是mGluR4的部分激动剂，EC50值为2.35 μM。

GC34957 (+)-Cevimeline hydrochloride hemihydrate

(-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate

(_addition_)-Cevimeline盐酸水合物是mAChR激动剂。

GC19546 AMG-510 racemate

AMG-510(消旋体),AMG-510 racemate

A covalent inhibitor of K-Ras^G12C

GC45259 (+)-Cloprostenol (sodium salt)

氯前列烯醇钠

The active isomer of cloprostenol, a potent IP receptor agonist

GC45157 WAY-161503

WAY161503盐酸盐

A 5-HT_2C receptor agonist

GC45150 Voacamine

老刺木胺

An alkaloid with diverse biological activities

GC45111 UDP-α-D-Glucose (sodium salt)

二磷酸尿苷葡萄糖二钠盐,UDP-D-Glucose disodium salt; Uridine 5′-diphosphoglucose disodium salt

A stereoisomer of UDP-α-D-glucose

GC44978 Syk Inhibitor II

Spleen Tyrosine Kinase Inhibitor II

A selective blocker of spleen tyrosine kinase activity

GC44875 SB-242084 (hydrochloride)

6-氯-2,3-二氢-5-甲基-N-[6-[(2-甲基-3-吡啶基)氧]-3-吡啶基]-1H-吲哚-1-酰胺盐酸盐

Specific antagonist of 5-HT_2C

GC44680 Pregnenolone sulfate (sodium salt)

3β-Hydroxy-5-pregnen-20-one monosulfate sodium

Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA_AR）的IC₅₀值为26±2μmol/L，对不含γ亚基的GABA_AR的IC₅₀值为18±3μmol/L。

GC44678 Prednisolone Phosphate (sodium salt)

泼尼松龙21-磷酸二钠; Prednisolone 21-phosphate disodium

A prodrug form of prednisolone

GC44673 PQ-10

6,7-二甲氧基-4-[(3R)-3-(2-喹喔啉基氧基)-1-吡咯烷基]喹唑啉

A selective PDE10 inhibitor

GC44601 Perlapine

MP-11

An atypical neuroleptic

GC44588 Peimisine (hydrochloride)

贝母辛盐酸盐,Ebeiensine hydrochloride

A steroidal alkaloid

GC44526 Oxytocin (acetate)

醋酸催产素; 醋酸缩宫素; α-Hypophamine acetate; Oxytocic hormone acetate

A peptide hormone best known for its role in reproductive biology

GC44360 Nedocromil (sodium salt)

奈多罗米钠,FPL 59002KP; Nedocromil disodium salt

A mast cell stabilizer

GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil

GC44350 N-Desmethyl Sildenafil

N-去甲基西地那非,Desmethylsildenafil; UK-103,320

A major metabolite of sildenafil

GC44311 Naftopidil (hydrochloride)

KT-611 hydrochloride; BM-15275 hydrochloride

An α₁-adrenergic receptor antagonist