Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC44416N-methyl Mesoporphyrin IXCAS: 142234-85-3纯度: >95.00% / >97.50%
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K d 值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
- GC44441N-Oleoyl LeucineCAS: 136560-76-4纯度: >98.00%
An N-acyl amide involved in mitochondrial uncoupling
- GC44451Norfluoxetine (hydrochloride)CAS: 57226-68-3纯度: >98.00%
Norfluoxetine (hydrochloride)是Fluoxetine在肝脏中通过N-去甲基化产生的活性代谢物，具有口服活性。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC44348 | N-desmethyl Bendamustine | 41515-13-3 | >95.00% | |
An active metabolite of bendamustine | ||||
| GC44349 | N-desmethyl Levofloxacin | 117707-40-1 | >98.00% | |
An active metabolite of levofloxacin | ||||
| GC44350 | N-Desmethyl Sildenafil | 139755-82-1 | >98.00% | |
A major metabolite of sildenafil | ||||
| GC44351 | N-Desmethyl Sildenafil (citrate) | - | >98.00% | |
A major metabolite of sildenafil | ||||
| GC44353 | NDMC101 | 1308631-40-4 | >99.50% | |
A salicylanilide derivative | ||||
| GC44358 | Nebivolol O-β-D-Glucuronide | - | >95.00% | |
An active metabolite of nebivolol | ||||
| GC44409 | Nivalenol | 23282-20-4 | >99.00% | |
A trichothecene mycotoxin | ||||
| GC44415 | N-methyl Leukotriene C4 | 131391-65-6 | >97.00% | |
A stable LTC 4 mimetic | ||||
| GC44416 | N-methyl Mesoporphyrin IX | 142234-85-3 | >95.00% / >97.50% | |
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K d 值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。 | ||||
| GC44431 | nNOS Inhibitor I | 357965-99-2 | >95.00% | |
A selective inhibitor of nNOS | ||||
| GC44441 | N-Oleoyl Leucine | 136560-76-4 | >98.00% | |
An N-acyl amide involved in mitochondrial uncoupling | ||||
| GC44444 | N-Oleoyl Valine | 60374-41-6 | >98.00% | |
A TRPV3 antagonist | ||||
| GC44451 | Norfluoxetine (hydrochloride) | 57226-68-3 | >98.00% | |
Norfluoxetine (hydrochloride)是Fluoxetine在肝脏中通过N-去甲基化产生的活性代谢物，具有口服活性。 | ||||
| GC44464 | NSC 109555 | 15427-93-7 | >98.00% | |
An inhibitor of Chk2 | ||||
| GC44488 | Octanoyl Coenzyme A (sodium salt) | - | >95.00% | |
A medium-chain acyl CoA | ||||
| GC44490 | Octanoyl-L-carnitine (chloride) | 54377-02-5 | >98.00% | |
A medium-chain acylcarnitine | ||||
| GC44492 | O-Desmethyl Metoprolol | 62572-94-5 | >99.00% | |
A major active metabolite of metoprolol | ||||
| GC44506 | Oligomycin D | 1404-59-7 | >95.00% | |
An inhibitor of mitochondrial F 1 F O -ATPase | ||||
| GC44509 | Omeprazole sulfide | 73590-85-9 | >99.50% | |
An intermediate for omeprazole synthesis | ||||
| GC44527 | p,p'-DDE | 72-55-9 | >99.50% | |
A metabolite and degradation product of the pesticide DDT | ||||
| GC44550 | Palmitoyl-D-carnitine (chloride) | 28330-02-1 | >98.00% | |
A long-chain acylcarnitine | ||||
| GC44551 | Palmitoyl-L-carnitine (chloride) | 18877-64-0 | >98.00% | |
A long-chain acylcarnitine | ||||
| GC44554 | Pantoprazole Sulfide | 102625-64-9 | >98.00% | |
A pantoprazole metabolite | ||||
| GC44555 | Pantoprazole sulfone | 127780-16-9 | >98.00% | |
A pantoprazole metabolite | ||||