Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC44635Phosphoenolpyruvic Acid (potassium salt)CAS: 4265-07-0纯度: >99.50% / >99.00%
An enzyme substrate for glycolysis and gluconeogenesis pathways
- GC44680Pregnenolone sulfate (sodium salt)CAS: 1852-38-6纯度: >95.00% / >98.00%
Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA A R）的IC 50 值为26±2μmol/L，对不含γ亚基的GABA A R的IC 50 值为18±3μmol/L。
- GC44795Miquelianin (Quercetin 3-O-glucuronide)CAS: 22688-79-5纯度: >99.50% / >98.00%
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。
- GC44803rac-7-hydroxy Propranolol (hydrochloride)CAS: 76275-67-7纯度: >98.00%
An isomer and metabolite of propranolol
- GC44820Resveratrol-3-O-Sulfate (sodium salt)CAS: 858127-11-4纯度: >95.00%
An active metabolite of resveratrol
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC44579 | PCTR1 | 1810710-59-8 | >96.00% | |
A specialized pro-resolving mediator | ||||
| GC44580 | PCTR2 | 1810710-63-4 | >96.00% | |
A specialized pro-resolving mediator | ||||
| GC44581 | PCTR3 | 1810710-69-0 | >96.00% | |
A specialized pro-resolving mediator | ||||
| GC44592 | Pentacosanoic Acid | 506-38-7 | >98.00% | |
A saturated long-chain fatty acid | ||||
| GC44599 | Perindoprilat | 95153-31-4 | >95.00% | |
An active ACE inhibitor | ||||
| GC44627 | Phenylephrine Glucuronide | 2021255-73-0 | >95.00% | |
A metabolite of phenylephrine | ||||
| GC44628 | Phenylephrine-3-O-Sulfate | 1242184-39-9 | >85.00% | |
A metabolite of phenylephrine | ||||
| GC44635 | Phosphoenolpyruvic Acid (potassium salt) | 4265-07-0 | >99.50% / >99.00% | |
An enzyme substrate for glycolysis and gluconeogenesis pathways | ||||
| GC44650 | Pitavastatin lactone | 141750-63-2 | >98.00% | |
A major phase 2 metabolite of pitavastatin | ||||
| GC44659 | PKSI-527 | 128837-71-8 | >95.00% | |
An inhibitor of plasma kallikrein | ||||
| GC44665 | PNU 142300 | 368891-69-4 | >95.00% | |
An inactive metabolite of linezolid | ||||
| GC44668 | Posaconazole D-Glucuronide | - | >80.00% | |
A metabolite of posaconazole | ||||
| GC44676 | Pravastatin lactone | 85956-22-5 | >98.00% | |
A metabolite of pravastatin | ||||
| GC44680 | Pregnenolone sulfate (sodium salt) | 1852-38-6 | >95.00% / >98.00% | |
Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA A R）的IC 50 值为26±2μmol/L，对不含γ亚基的GABA A R的IC 50 值为18±3μmol/L。 | ||||
| GC44699 | Propranolol β-D-Glucuronide (sodium salt) | - | >95.00% | |
A major metabolite of propranolol | ||||
| GC44785 | Pyridoxal 5'-phosphate (hydrate) | 853645-22-4 | >95.00% | |
An enzyme cofactor | ||||
| GC44793 | Pyrroloquinoline quinone | 72909-34-3 | >97.00% | |
据报道，吡咯并喹啉醌是一种新的哺乳动物乳酸脱氢酶 (LDH) 辅酶。 | ||||
| GC44795 | Miquelianin (Quercetin 3-O-glucuronide) | 22688-79-5 | >99.50% / >98.00% | |
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。 | ||||
| GC44799 | Quinidine N-oxide | 70116-00-6 | >95.00% | |
A quinidine metabolite | ||||
| GC44803 | rac-7-hydroxy Propranolol (hydrochloride) | 76275-67-7 | >98.00% | |
An isomer and metabolite of propranolol | ||||
| GC44810 | Reduced Haloperidol | 34104-67-1 | >98.00% | |
An active metobolite of haloperidol | ||||
| GC44815 | Resolvin D1 | 872993-05-0 | ≥95.00% | |
A product of the action of 15- and 5-LO on DHA | ||||
| GC44818 | Resolvin D4 | 1025684-60-9 | >95.00% | |
A pro-resolving mediator | ||||
| GC44820 | Resveratrol-3-O-Sulfate (sodium salt) | 858127-11-4 | >95.00% | |
An active metabolite of resveratrol | ||||