Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC44890Silodosin Glucuronide (sodium salt)CAS: 879292-24-7纯度: >95.00%
An active metabolite of silodosin
- GC44895Sitagliptin N-Sulfate (sodium salt)CAS: 2470126-25-9纯度: >95.00%
A metabolite of (–)-sitagliptin
- GC44908sn-Glycerol-3-phosphate (cyclohexyl ammonium salt)CAS: 29849-82-9纯度: >95.00%
A lipid biosynthesis intermediate
- GC44928Sphingomyelins (from bovine spinal cord)CAS: 85187-10-6纯度: >95.00% (natural bovine mixture)
A sphingolipid
- GC44992Taurochenodeoxycholic Acid (sodium salt)CAS: 6009-98-9纯度: >98.00%
Taurochenodeoxycholic Acid (sodium salt)是一种内源性亲水性胆汁酸，是由胆汁酸中的天然成分熊去氧胆酸（UDCA）在肝脏中与氨基酸牛磺酸进行化学结合形成的。Taurochenodeoxycholic Acid (sodium salt)已被批准用于治疗肝脏疾病。Taurochenodeoxycholic Acid (sodium salt)可以减少活性氧的形成，防止线粒体功能障碍，并降低细胞凋亡的阈值。
- GC45007Telmisartan Acyl-β-D-GlucuronideCAS: 250780-40-6纯度: >95.00%
A major metabolite of telmisartan
- GC45012Tenofovir diphosphate (sodium salt)纯度: >95.00%
An HIV reverse transcriptase and HBV polymerase inhibitor
- GC45031Thiamine (hydrochloride)CAS: 67-03-8纯度: >98.00% / >99.00%
Thiamine (hydrochloride)是一种水溶性必需微量营养素，Thiamine易透过血脑屏障，是研究能量代谢、神经炎症及衰老相关代谢功能障碍的重要工具化合物。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC44860 | S1QEL1.1 | 897613-29-5 | >98.00% | |
A suppressor of I Q electron leak | ||||
| GC44862 | S3QEL-2 | 890888-12-7 | >99.50% | |
A suppressor of mitochondrial electron leak | ||||
| GC44867 | SAICAR | 3031-95-6 | >98.00% / >99.00% | |
SAICAR是嘌呤核苷酸从头合成途径中的一种中间代谢产物，SAICAR能够以同工酶选择性的方式激活丙酮酸激酶M2亚型（PKM2；EC 50 =0.3mM）。 | ||||
| GC44874 | Saxagliptin (hydrochloride) | 709031-78-7 | >98.00% | |
A potent DPP-4 inhibitor | ||||
| GC44879 | Sclerotiorin | 549-23-5 | >98.00% | |
A natural compound with LOX and CETP inhibitory activity | ||||
| GC44890 | Silodosin Glucuronide (sodium salt) | 879292-24-7 | >95.00% | |
An active metabolite of silodosin | ||||
| GC44891 | Simeprevir (sodium salt) | 1241946-89-3 | >98.00% | |
A potent NS3/4A protease inhibitor | ||||
| GC44895 | Sitagliptin N-Sulfate (sodium salt) | 2470126-25-9 | >95.00% | |
A metabolite of (–)-sitagliptin | ||||
| GC44908 | sn-Glycerol-3-phosphate (cyclohexyl ammonium salt) | 29849-82-9 | >95.00% | |
A lipid biosynthesis intermediate | ||||
| GC44912 | Solifenacin N-Glucuronide | - | >85.00% | |
A metabolite of solifenacin | ||||
| GC44913 | Solifenacin N-oxide | 180272-28-0 | >98.00% | |
An inactive metabolite of solifenacin | ||||
| GC44917 | Sorafenib N-oxide | 583840-03-3 | >98.00% | |
An active metabolite of sorafenib | ||||
| GC44928 | Sphingomyelins (from bovine spinal cord) | 85187-10-6 | >95.00% (natural bovine mixture) | |
A sphingolipid | ||||
| GC44951 | Stearoyl-L-carnitine (chloride) | 32350-57-5 | >95.00% | |
A long-chain acylcarnitine | ||||
| GC44982 | T-2 Triol | 34114-98-2 | >98.00% | |
An active metabolite of T-2 toxin | ||||
| GC44990 | Tanomastat | 179545-77-8 | >98.00% | |
An inhibitor of MMP-2, -3, and -9 | ||||
| GC44992 | Taurochenodeoxycholic Acid (sodium salt) | 6009-98-9 | >98.00% | |
Taurochenodeoxycholic Acid (sodium salt)是一种内源性亲水性胆汁酸，是由胆汁酸中的天然成分熊去氧胆酸（UDCA）在肝脏中与氨基酸牛磺酸进行化学结合形成的。Taurochenodeoxycholic Acid (sodium salt)已被批准用于治疗肝脏疾病。Taurochenodeoxycholic Acid (sodium salt)可以减少活性氧的形成，防止线粒体功能障碍，并降低细胞凋亡的阈值。 | ||||
| GC44995 | Taurodeoxycholic Acid (sodium salt) | 1180-95-6 | >98.00% | |
牛磺脱氧胆酸 (TDCA) 是一种胆汁盐，通常存在于肠腔内。 | ||||
| GC45001 | Tazarotenic Acid | 118292-41-4 | >98.00% | |
An active metabolite of tazarotene | ||||
| GC45007 | Telmisartan Acyl-β-D-Glucuronide | 250780-40-6 | >95.00% | |
A major metabolite of telmisartan | ||||
| GC45012 | Tenofovir diphosphate (sodium salt) | - | >95.00% | |
An HIV reverse transcriptase and HBV polymerase inhibitor | ||||
| GC45020 | Tetrachlorohydroquinone | 87-87-6 | >98.00% | |
A metabolite of pentachlorophenol | ||||
| GC45024 | tetranor-12(S)-HETE | 121842-79-3 | - | |
A peroxisome metabolite of 12(S)-HETE | ||||
| GC45031 | Thiamine (hydrochloride) | 67-03-8 | >98.00% / >99.00% | |
Thiamine (hydrochloride)是一种水溶性必需微量营养素，Thiamine易透过血脑屏障，是研究能量代谢、神经炎症及衰老相关代谢功能障碍的重要工具化合物。 | ||||