Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC45066Tosyl Phenylalanyl Chloromethyl KetoneCAS: 402-71-1纯度: >97.00%
An inhibitor of chymotrypsin-like serine proteases
- GC45086Trigalacturonic AcidCAS: 6037-45-2纯度: >95.00%
三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。
- GC45111UDP-α-D-Glucose (sodium salt)CAS: 28053-08-9纯度: >99.50% / >98.00%
A stereoisomer of UDP-α-D-glucose
- GC45135Validamycin ACAS: 37248-47-8纯度: >60.00%
Validamycin A是一种通过抑制海藻糖酶（trehalase）保护作物免受真菌Rhizoctonia solani侵害的农用抗生素类杀菌剂，IC 50 值为72μM。
- GC45144Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)CAS: 565453-41-0纯度: >98.00%
A major metabolite of vildagliptin
- GC45179ZeaxanthinCAS: 144-68-3纯度: >98.00%
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。
- GC45204α-EcdysoneCAS: 3604-87-3纯度: >95.00%
蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
- GC45226β-BHCCAS: 319-85-7纯度: 95.00%
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
- GC45252(-)-Sitagliptin Carbamoyl GlucuronideCAS: 940002-59-5纯度: >90.00%
A minor phase II metabolite of (–)-sitagliptin
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC45066 | Tosyl Phenylalanyl Chloromethyl Ketone | 402-71-1 | >97.00% | |
An inhibitor of chymotrypsin-like serine proteases | ||||
| GC45084 | Tridecanoic Acid | 638-53-9 | >98.00% | |
A 13-carbon saturated fatty acid | ||||
| GC45086 | Trigalacturonic Acid | 6037-45-2 | >95.00% | |
三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。 | ||||
| GC45090 | Triparanol | 78-41-1 | >98.00% | |
An inhibitor of DHCR24 | ||||
| GC45109 | Ubiquinol | 992-78-9 | >90.00% / >95.00% | |
A reduced form of coenzyme Q 10 | ||||
| GC45111 | UDP-α-D-Glucose (sodium salt) | 28053-08-9 | >99.50% / >98.00% | |
A stereoisomer of UDP-α-D-glucose | ||||
| GC45134 | Valeryl-L-carnitine (chloride) | 162040-64-4 | >98.00% | |
A short-chain acylcarnitine | ||||
| GC45135 | Validamycin A | 37248-47-8 | >60.00% | |
Validamycin A是一种通过抑制海藻糖酶（trehalase）保护作物免受真菌Rhizoctonia solani侵害的农用抗生素类杀菌剂，IC 50 值为72μM。 | ||||
| GC45137 | Valproic Acid Acyl-D-Glucuronide | - | >95.00% | |
A metabolite of valproic acid | ||||
| GC45144 | Vildagliptin carboxylic acid metabolite (trifluoroacetate salt) | 565453-41-0 | >98.00% | |
A major metabolite of vildagliptin | ||||
| GC45151 | Voriconazole N-oxide | 618109-05-0 | >95.00% | |
A major metabolite of voriconazole | ||||
| GC45175 | YVAD-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-1/ICE inhibitor | ||||
| GC45177 | Z-AEVD-FMK | 1135688-47-9 | >95.00% | |
A caspase-10 inhibitor | ||||
| GC45178 | Z-DEVD-CMK (trifluoroacetate salt) | - | >95.00% | |
An irreversible protease inhibitor | ||||
| GC45179 | Zeaxanthin | 144-68-3 | >98.00% | |
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。 | ||||
| GC45189 | Z-VAD(OH)-FMK | 161401-82-7 | >99.00% / >98.00% | |
Z-VAD(OH)-FMK是所有半胱天冬酶的不可逆三肽抑制剂。 | ||||
| GC45192 | Z-VRPR-FMK (trifluoroacetate salt) | - | >90.00% | |
An irreversible inhibitor of MALT1 | ||||
| GC45193 | Z-YVAD-CMK (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of caspase-1 and caspase-3 | ||||
| GC45204 | α-Ecdysone | 3604-87-3 | >95.00% | |
蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。 | ||||
| GC45208 | α-hydroxy Metoprolol | 56392-16-6 | >98.00% | |
An active metabolite of metoprolol | ||||
| GC45226 | β-BHC | 319-85-7 | 95.00% | |
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. | ||||
| GC45245 | (-)-Caryophyllene oxide | 1139-30-6 | >98.00% | |
A bicyclic sesquiterpene | ||||
| GC45252 | (-)-Sitagliptin Carbamoyl Glucuronide | 940002-59-5 | >90.00% | |
A minor phase II metabolite of (–)-sitagliptin | ||||
| GC45339 | 3-Oxocholic Acid | 2304-89-4 | >98.00% | |
A secondary bile acid | ||||