3-Oxocholic acid is a secondary bile acid and a metabolite of cholic acid in C. perfringens, a bacteria found in the intestines of mammals and in the environment.[1],[2] 3-Oxocholic acid serum levels increase following ileal transposition surgery in rats.[3]
References
[1]. Wahlstr•m, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[2]. Macdonald, I.A., Forrest, T.P., Costain, G.A., et al. Identification of 7α-, 12α-dihydroxy-3-oxo cholanoic acid as the major degradation product from cholic by C. perfringens. J. Steroid Biochem. 9(4), 353-358 (1978).
[3]. Yan, K., Chen, W., Zhu, H., et al. The changes of serum metabolites in diabetic GK rats after ileal transposition surgery. Obes. Surg. 29(3), 882-890 (2019).