Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC453414-Amino-6-chloro-1,3-benzenedisulfonamideCAS: 121-30-2纯度: >98.00%
A carbonic anhydrase inhibitor
- GC45398Captopril-d3CAS: 1356383-38-4纯度: >99.00%
An internal standard for the quantification of captopril
- GC45410cis-6-Hexadecenoic Acid-d19CAS: 2692623-89-3纯度: >99.00%
An internal standard for the quantification of cis-6-hexadecenoic acid
- GC45518N1-Acetylspermidine (hydrochloride)CAS: 34450-16-3纯度: >99.50% / >98.00%
N1-Acetylspermidine (hydrochloride)是亚精胺的一种乙酰化衍生物，可作为多胺氧化酶（PAO）的底物。
- GC45580Tizoxanide-d4CAS: 1246817-56-0纯度: >99.00%
An internal standard for the quantification of tizoxanide
- GC456153-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)纯度: >95.00%
A neuropeptide with diverse biological activities
- GC45818Metoclopramide-d3CAS: 1216522-89-2纯度: >99.00%
An internal standard for the quantification of metoclopramide
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC45341 | 4-Amino-6-chloro-1,3-benzenedisulfonamide | 121-30-2 | >98.00% | |
A carbonic anhydrase inhibitor | ||||
| GC45385 | Ara-G | 38819-10-2 | >95.00% | |
An anticancer nucleoside analog | ||||
| GC45390 | Benazepril Acyl-β-D-Glucuronide | - | >95.00% | |
A metabolite of benazepril | ||||
| GC45398 | Captopril-d3 | 1356383-38-4 | >99.00% | |
An internal standard for the quantification of captopril | ||||
| GC45410 | cis-6-Hexadecenoic Acid-d19 | 2692623-89-3 | >99.00% | |
An internal standard for the quantification of cis-6-hexadecenoic acid | ||||
| GC45436 | Diprotin A | 90614-48-5 | >99.00% | |
A tripeptide inhibitor of DPP-4 | ||||
| GC45440 | Doxycycline-d3 (hyclate) | - | >99.00% | |
一种用于量化多西环素的内部标准 | ||||
| GC45449 | Erythromycylamine | 26116-56-3 | >95.00% | |
A macrolide antibiotic | ||||
| GC45494 | Lavendustin B | 125697-91-8 | >98.00% | |
An inhibitor of Glut1 | ||||
| GC45508 | MEGX (hydrochloride) | 7729-94-4 | >95.00% | |
An active metabolite of lidocaine | ||||
| GC45515 | MX1013 | 582316-00-5 | >98.00% | |
A dipeptide pan-caspase inhibitor | ||||
| GC45518 | N1-Acetylspermidine (hydrochloride) | 34450-16-3 | >99.50% / >98.00% | |
N1-Acetylspermidine (hydrochloride)是亚精胺的一种乙酰化衍生物，可作为多胺氧化酶（PAO）的底物。 | ||||
| GC45580 | Tizoxanide-d4 | 1246817-56-0 | >99.00% | |
An internal standard for the quantification of tizoxanide | ||||
| GC45599 | Z-Phe-Tyr(tBu)-diazomethylketone | 114014-15-2 | >98.00% | |
An inhibitor of cathepsin L | ||||
| GC45615 | 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt) | - | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC45650 | Des(benzylpyridyl) Atazanavir | 1192224-24-0 | >98.00% | |
A metabolite of atazanavir | ||||
| GC45673 | 7,8-Dihydroneopterin | 1218-98-0 | >85.00% | |
An antioxidant | ||||
| GC45687 | Dasatinib N-oxide | 910297-52-8 | >95.00% | |
A major metabolite of dasatinib | ||||
| GC45705 | D-Kynurenine | 13441-51-5 | >98.50% | |
An antagonist of GPR109B | ||||
| GC45766 | Amprenavir-d4 | 2738376-78-6 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC45768 | Pranlukast-d4 | 2713172-43-9 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC45800 | Cytarabine-13C3 | - | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC45818 | Metoclopramide-d3 | 1216522-89-2 | >99.00% | |
An internal standard for the quantification of metoclopramide | ||||
| GC45909 | 17α-hydroxy Pregnenolone | 387-79-1 | >95.00% | |
A metabolite of pregnenolone | ||||