GlpBio

Oligomycin D

目录号: GC44506纯度: >95.00%同义词: 芦他霉素,26-Demethyloligomycin A
An inhibitor of mitochondrial F1FO-ATPase
Oligomycin D
Cas No.: 1404-59-7
规格价格库存数量操作
2.5mg¥11,565.00现货
1
500μg¥5,159.00现货
1
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产品描述 Description

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. [1] Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 µM.[2]

Reference:
[1]. Inoue, S., Mizutani, A., Sugita, R., et al. Purification and characterization of a novel protein activator of Ca2+/calmodulin-dependent protein kinase I. Biochemical and Biophysical Research Communications 215(3), 861-867 (1995).
[2]. Salim, A.A., Tan, L., Huang, X.-C., et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Organic & Biomolecular Chemistry 14(2), 711-715 (2016).

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
1404-59-7
同义词
芦他霉素,26-Demethyloligomycin A
化学名
(1S,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione
SMILES
C[C@H](C[C@H]1[C@@H](C)CC[C@@]2(C[C@@H]([C@@]([H])([C@@H](O2)CC[C@@]([H])(CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](O)(C3=O)C)C)OC(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]3C)=O)=O)O1)O
分子式
C44H72O11
分子量
777 g/mol
溶解性
Soluble in methanol, or in ethanol, or in DMSO, or in DMF
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol