Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC44212MK-886 (sodium salt)CAS: 118427-55-7纯度: >99.00%
A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
- GC44284N1,N8-Diacetylspermidine (hydrochloride)CAS: 178244-42-3纯度: >98.00%
An acetyl derivative of spermidine
- GC44295N-acetyl Leukotriene E4CAS: 80115-95-3纯度: >97.00%
The major inactive metabolite of LTE 4 found in bile
- GC44299N-Acetyl-4-benzoquinone imineCAS: 50700-49-7纯度: >90.00%
A reactive CYP450 metabolite of acetaminophen
- GC44306N-acetyl-S-geranylgeranyl-L-CysteineCAS: 139332-94-8纯度: >95.00%
A synthetic substrate for the SAM-dependent methyltransferase
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC44201 | MitoP | 74597-01-6 | >95.00% | |
The end product of a mitochondrial matrix H 2 O 2 probe reaction | ||||
| GC44202 | MitoPBN | 652968-37-1 | >95.00% | |
A mitochondria-targeted antioxidant | ||||
| GC44203 | MitoPerOx | 1392820-50-6 | >95.00% | |
A ratiometric fluorescent probe for mitochondrial lipid peroxidation | ||||
| GC44204 | MitoPQ | 1821370-28-8 | >98.00% | |
MitoPQ （ MitoParaquat）是一种可选择性增加体内和细胞线粒体基质内超氧化物产生的线粒体靶向氧化还原循环剂。 | ||||
| GC44205 | Mitoquinol | 845959-55-9 | >98.00% | |
A mitochondria-targeted antioxidant | ||||
| GC44206 | MitoTEMPO (hydrate) | 1569257-94-8 | >95.00% / >98.00% | |
A mitochondria-targeted antioxidant | ||||
| GC44207 | MitoTEMPOL | 1101113-39-6 | >98.00% | |
A mitochondrial-targeting SOD mimetic | ||||
| GC44212 | MK-886 (sodium salt) | 118427-55-7 | >99.00% | |
A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP) | ||||
| GC44214 | ML-162 | 1035072-16-2 | >99.50% | |
ML-162是一种可抑制谷胱甘肽过氧化物酶4（GPX4）的小分子化合物，IC 50 值为1.42μM。 | ||||
| GC44236 | MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of MMP-2 and MMP-9 | ||||
| GC44237 | MMP-9 Inhibitor I | 206549-55-5 | >95.00% | |
An inhibitor of MMP-9 | ||||
| GC44246 | Moxifloxacin N-Sulfate (sodium salt) | - | >95.00% | |
A metabolite of moxifloxacin | ||||
| GC44262 | Myristoyl-L-carnitine (chloride) | 173686-73-2 | >98.00% | |
A long-chain acylcarnitine | ||||
| GC44284 | N1,N8-Diacetylspermidine (hydrochloride) | 178244-42-3 | >98.00% | |
An acetyl derivative of spermidine | ||||
| GC44294 | N-acetyl Dapsone | 565-20-8 | >95.00% | |
A metabolite of dapsone | ||||
| GC44295 | N-acetyl Leukotriene E4 | 80115-95-3 | >97.00% | |
The major inactive metabolite of LTE 4 found in bile | ||||
| GC44299 | N-Acetyl-4-benzoquinone imine | 50700-49-7 | >90.00% | |
A reactive CYP450 metabolite of acetaminophen | ||||
| GC44304 | N-Acetyl-S-allyl-L-cysteine | 23127-41-5 | >98.00% | |
A primary metabolite of L-deoxyalliin | ||||
| GC44306 | N-acetyl-S-geranylgeranyl-L-Cysteine | 139332-94-8 | >95.00% | |
A synthetic substrate for the SAM-dependent methyltransferase | ||||
| GC44307 | NADP+ | 53-59-8 | >90.00% / >98.00% | |
NADP+ 是电子供体烟酰胺腺嘌呤二核苷酸磷酸的氧化形式。 | ||||
| GC44308 | NADP+ (sodium salt hydrate) | 698999-85-8 | >95.00% | |
The oxidized form of NADPH | ||||
| GC44338 | NCT-501 (hydrochloride) | 2080306-22-3 | >98.00% | |
A reversible inhibitor of ALDH1A1 | ||||
| GC44341 | ND-336 | 1807453-83-3 | >95.00% | |
A selective inhibitor of MMP-2, -9, and -14 | ||||
| GC44345 | N-Desethyl Vardenafil | 448184-46-1 | >98.00% | |
A vardenafil metabolite | ||||