NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. NADP+ together with its reduced form, reduced NADPH, is involved in maintaining redox balance and supporting the biosynthesis of fatty acids and nucleic acids [1].
NADP+, a structural analogue of NAD+, is synthesized by transferring a phosphate group from ATP to the 2′-hydroxyl group of the adenosine ribose moiety of NAD+. This reaction is catalyzed by NADKs [2]. NADP+ act as a cofactor in various biological reactions [3]. NADP+/NADPH is important in regulating the cellular redox state, energy metabolism, mitochondrial function, gene expression, and signaling pathways, NADP+/NADPH are essential for maintaining a large array of biological processes[3,4,5].
References:
[1]. Yang, Yue, and Anthony A. Sauve. "NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864.12 (2016): 1787-1800.
[2]. Ying, Weihai. "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences." Antioxidants & redox signaling 10.2 (2008): 179-206.
[3]. Jackson J B. A review of the binding-change mechanism for proton-translocating transhydrogenase[J]. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012, 1817(10): 1839-1846.
[4]. Cantó, Carles, and Johan Auwerx. "NAD+ as a signaling molecule modulating metabolism." Cold Spring Harbor symposia on quantitative biology. Vol. 76. Cold Spring Harbor Laboratory Press, 2011.
[5]. Cantó, Carles, Keir J. Menzies, and Johan Auwerx. "NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus." Cell metabolism 22.1 (2015): 31-53.
NADP+ 是电子供体烟酰胺腺嘌呤二核苷酸磷酸的氧化形式。 NADP+ 及其还原型 NADPH 参与维持氧化还原平衡并支持脂肪酸和核酸的生物合成[1]。
NADP+ 是 NAD+ 的结构类似物，通过将磷酸基团从 ATP 转移到 NAD+ 的腺苷核糖部分的 2'-羟基而合成。该反应由 NADKs [2] 催化。 NADP+ 在多种生物反应中作为辅助因子[3]。 NADP+/NADPH在调节细胞氧化还原状态、能量代谢、线粒体功能、基因表达和信号通路方面具有重要作用，NADP+/NADPH对维持大量生物过程至关重要[3,4,5].