Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC43903Indoxyl Sulfate (potassium salt)CAS: 2642-37-7纯度: >98.00%
硫酸吲哚酚(Indoxyl sulfate (IS)),又称3-吲哚酚硫酸和3-吲哚酚硫酸,是膳食l -色氨酸的代谢物,具有心脏毒素和尿毒症毒素的作用。
- GC43904Inosine 5'-triphosphate (sodium salt)CAS: 35908-31-7纯度: >98.00% / >99.50%
A nucleoside triphosphate
- GC43912IsoapoptolidinCAS: 476647-30-0纯度: >90.00%
Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
- GC43922Isovaleryl-L-carnitine (chloride)CAS: 139144-12-0纯度: >95.00% / >98.00%
Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡。
- GC44053Leukotriene B4 EthanolamideCAS: 877459-63-7纯度: >97.00%
A theoretical 5-LO metabolite of arachidonoyl ethanolamide
- GC44054Leukotriene C4 methyl esterCAS: 73958-10-8纯度: >97.00%
A more lipid soluble formulation of LTE 4
- GC44061L-Homoarginine (hydrochloride)CAS: 1483-01-8纯度: >98.00% / >95.00%
An uncompetitive inhibitor of alkaline phosphatases
- GC44079L-Leucyl-L-Leucine methyl ester (hydrochloride)CAS: 6491-83-4纯度: >98.00%
L-Leucyl-L-Leucine methyl ester (hydrochloride)是一种溶酶体缩合产物，对自然杀伤细胞和CD4 + 及CD8 + T淋巴细胞具有细胞毒性，但不影响辅助性T细胞和B细胞。
- GC44186Metoclopramide (hydrochloride)CAS: 7232-21-5纯度: >98.00%
An orally bioavailable 5-HT 3 and D 2 receptor antagonist
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC43903 | Indoxyl Sulfate (potassium salt) | 2642-37-7 | >98.00% | |
硫酸吲哚酚(Indoxyl sulfate (IS)),又称3-吲哚酚硫酸和3-吲哚酚硫酸,是膳食l -色氨酸的代谢物,具有心脏毒素和尿毒症毒素的作用。 | ||||
| GC43904 | Inosine 5'-triphosphate (sodium salt) | 35908-31-7 | >98.00% / >99.50% | |
A nucleoside triphosphate | ||||
| GC43909 | Iromycin A | 213137-53-2 | >98.00% | |
A natural eNOS inhibitor | ||||
| GC43912 | Isoapoptolidin | 476647-30-0 | >90.00% | |
Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively). | ||||
| GC43922 | Isovaleryl-L-carnitine (chloride) | 139144-12-0 | >95.00% / >98.00% | |
Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡。 | ||||
| GC44019 | L-(+)-Ergothioneine | 497-30-3 | >98.50% | |
L-(+)-Ergothioneine是一种含硫的组氨酸衍生物，是一种有效的抗氧化剂。 | ||||
| GC44029 | L-Alanyl-L-Glutamine | 39537-23-0 | >99.00% | |
A synthetic glutamine dipeptide | ||||
| GC44033 | Lansoprazole sulfone | 131926-99-3 | >98.00% | |
A metabolite of lansoprazole | ||||
| GC44044 | Lauroyl-L-carnitine (chloride) | 6919-91-1 | >98.00% | |
月桂基-l-肉碱是一种天然存在的化合物，属于酰基肉碱家族。 | ||||
| GC44052 | Leukotriene B4 dimethyl amide | 83024-92-4 | >97.00% | |
A LTB 4 receptor antagonist | ||||
| GC44053 | Leukotriene B4 Ethanolamide | 877459-63-7 | >97.00% | |
A theoretical 5-LO metabolite of arachidonoyl ethanolamide | ||||
| GC44054 | Leukotriene C4 methyl ester | 73958-10-8 | >97.00% | |
A more lipid soluble formulation of LTE 4 | ||||
| GC44055 | Leukotriene D4 methyl ester | - | >97.00% | |
A more lipid soluble formulation of LTD 4 | ||||
| GC44056 | Leukotriene E4 methyl ester | - | >97.00% | |
A more lipid soluble formulation of LTE 4 | ||||
| GC44061 | L-Homoarginine (hydrochloride) | 1483-01-8 | >98.00% / >95.00% | |
An uncompetitive inhibitor of alkaline phosphatases | ||||
| GC44079 | L-Leucyl-L-Leucine methyl ester (hydrochloride) | 6491-83-4 | >98.00% | |
L-Leucyl-L-Leucine methyl ester (hydrochloride)是一种溶酶体缩合产物，对自然杀伤细胞和CD4 + 及CD8 + T淋巴细胞具有细胞毒性，但不影响辅助性T细胞和B细胞。 | ||||
| GC44083 | LP-533401 | 945976-43-2 | >98.00% | |
An inhibitor of gut-derived serotonin biosynthesis | ||||
| GC44093 | Lutein | 127-40-2 | >98.00% | |
Lutein是一种天然存在的类胡萝卜素，具有多种生物活性，广泛存在于绿叶蔬菜、玉米和蛋黄中。 | ||||
| GC44138 | MCTR1 | 1784701-61-6 | ≥95% | |
A specialized pro-resolving mediator | ||||
| GC44139 | MCTR2 | 1784701-62-7 | >97.00% | |
A specialized pro-resolving mediator | ||||
| GC44140 | MCTR3 | 1784701-63-8 | >98.00% | |
A specialized pro-resolving mediator | ||||
| GC44186 | Metoclopramide (hydrochloride) | 7232-21-5 | >98.00% | |
An orally bioavailable 5-HT 3 and D 2 receptor antagonist | ||||
| GC44198 | MitoA | - | >95.00% | |
A probe to detect H 2 S in mitochondria | ||||
| GC44199 | MitoB | 1247025-84-8 | >95.00% | |
A probe to detect H 2 O 2 in mitochondria | ||||