Isovaleryl-L-carnitine (chloride) is the analog of l-carnitine that delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells [1]. Isovaleryl-L-carnitine inhibits the proteolysis induced by amino acid deprivation in the perfused rat liver [2]. Isovaleryl-L-carnitine is widely used as an internal standard to develop a simple flow injection analysis-tandem mass spectrometry method for differentiating C5-acylcarnitine isomers[3].
References:
[1] Revoltella R P, Dal Canto B, Caracciolo L, et al. L-carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2. 8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1994, 1224(3): 333-341.
[2] Miotto G, Venerando R, Siliprandi N. Inhibitory action of isovaleryl-l-carnitine on proteolysis in perfused rat liver[J]. Biochemical and biophysical research communications, 1989, 158(3): 797-802.
[3] Hattori T, Notsu Y, Tanaka M, et al. A simple flow injection analysis–tandem mass spectrometry method to reduce false positives of C5-acylcarnitines due to pivaloylcarnitine using reference ions[J]. Children, 2022, 9(5): 694.
Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡[1]。Isovaleryl-L-carnitine抑制灌流大鼠肝脏中由氨基酸剥夺诱导的蛋白水解[2]。Isovaleryl-L-carnitine被广泛用作内标，以开发一种简单的流动注射分析-串联质谱法，用于区分C5-酰基肉碱异构体[3]。