GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC39173 structure
    GC39173Phosphorylcholine chloride calcium salt tetrahydrate
    CAS: 72556-74-2

    Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite.

  • GC39185 structure
    GC39185Pregnanediol
    CAS: 80-92-2
    纯度: >95.00% / >98.00%

    Pregnanediol是孕酮的主要代谢产物，通过尿液排出体外。

  • GC39199 structure
    GC39199Thymopentin acetate
    CAS: 89318-88-7
    纯度: >99.50%

    A pentapeptide fragment of thymopoietin

  • GC39215 structure
    GC39215CM10
    CAS: 692269-09-3
    纯度: >99.50%

    A pan-ALDH1A inhibitor

  • GC39223 structure
    GC3922311-Beta-hydroxyandrostenedione
    CAS: 382-44-5
    纯度: >98.50%

    11β-Hydroxyandrostenedione是一种内源性、天然存在的?类固醇和雄激素原，主要（如果不是完全）在肾上腺中产生。它与肾上腺产生的肾上腺素(11-ketoandrostenedione; 11-KA4)、11-ketotestosterone?(11-KT) 和11-ketodihydrotestosterone?(11-KDHT)密切相关。可用作指导肾上腺静脉取样中原发性醛固酮增多症亚型的生物标志物，其中从两个肾上腺采集血样以比较每个腺体产生的激素量。

  • GC39245 structure
    GC392454-Diethylaminobenzaldehyde
    CAS: 120-21-8
    纯度: >98.00%

    4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂，对 ALDH1 的 Ki 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC50= 1.71 μM)。

  • GC39251 structure
    GC39251Cinacalcet metabolite M4
    CAS: 104774-87-0

    Cinacalcet metabolite M4 是 Cinacalcet 的代谢物。Cinacalcet 是一种可口服的 Ca receptor (CaR) 激动剂，用于心血管疾病。

  • GC39256 structure
    GC39256LP-935509
    CAS: 1454555-29-3
    纯度: >99.50%

    LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM)，一种 ATP 竞争性抑制剂，其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。

  • GC39271 structure
    GC39271(±)-Naringenin
    CAS: 67604-48-2
    纯度: >98.50%

    A citrus- derived flavonoid

  • GC39279 structure
    GC39279hDHODH-IN-1
    CAS: 1173715-42-8
    纯度: >99.50%

    hDHODH-IN-1 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with anti-inflammatory effect.

  • GC39296 structure
    GC392961G244
    CAS: 847928-32-9
    纯度: >98.50%

    1G244 是一种有效的 DPP8/9 抑制剂，IC50 分别为 12 nM 和 84 nM，但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡，并具有抗骨髓瘤作用。

  • GC39306 structure
    GC39306D-Glucose 6-phosphate disodium salt
    CAS: 3671-99-6

    D-Glucose-6-phosphate disodium salt 称 6-磷酸葡萄糖，是葡萄糖经过磷酸化 (在第 6 号碳) 之后生成的分子。它是生物细胞中的常见分子，参与磷酸戊糖途径与糖酵解等生化途径。

  • GC39307 structure
    GC393074-Methylamino antipyrine
    CAS: 519-98-2
    纯度: >98.00%

    An active metabolite of metamizole

  • GC39327 structure
    GC393273,4-Dimethoxyphenol
    CAS: 2033-89-8
    纯度: >96.00%

    3,4-Dimethoxyphenol 是植物来源的苯基丙烷化合物，可在化妆品中用作增白剂。3,4-Dimethoxyphenol 具有酪氨酸酶 (tyrosinase) 抑制活性。从细菌发酵液中分离出的 3,4-Dimethoxyphenol 具有有效的抗氧化作用。

  • GC39328 structure
    GC393283-Hydroxybenzaldehyde
    CAS: 100-83-4
    纯度: >98.00%

    3-Hydroxybenzaldehyde (3-HBA), one of the benzaldehydes commonly found in nature, is produced by 3-hydroxybenzyl-alcohol dehydrogenase, and is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans (ALDH2). 3-Hydroxybenzaldehyde exhibits vasculoprotective effects.

  • GC39363 structure
    GC39363Cortodoxone
    CAS: 152-58-9
    纯度: >98.00% / >99.50%

    Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

  • GC39366 structure
    GC39366Creatinine-D3
    CAS: 143827-20-7
    纯度: >99.50% / >98.00%

    Creatinine-D3是一种氘标记的肌酸酐化合物。

  • GC39368 structure
    GC39368Dacisteine
    CAS: 18725-37-6
    纯度: >99.00%

    Dacisteine (N,S-Diacetyl-L-cysteine) 是一种半胱氨酸衍生物，具有很小的 (NDM-1) 抑制活性，IC50 值为 1000 μM。Dacisteine 可用于治疗血小板聚集引起的心脑血管疾病。

  • GC39373 structure
    GC39373Desmethyl ferroquine
    CAS: 903546-18-9
    纯度: >98.00%

    Desmethyl ferroquine (SSR97213) 是 Ferroquine 的主要活性代谢产物。Ferroquine 是一种抗疟剂。Desmethyl ferroquine 显著抑制对 Chloroquine 敏感的和耐 Chloroquine 的恶性疟原虫菌株 P. falciparum。

  • GC39392 structure
    GC39392Isomalt
    CAS: 64519-82-0
    纯度: >98.00%

    Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.

  • GC39404 structure
    GC39404Mebeverine alcohol
    CAS: 14367-47-6
    纯度: >97.50%

    Mebeverine alcohol是Mebeverine的代谢物。

  • GC39411 structure
    GC39411NL-1
    CAS: 188532-26-5
    纯度: >98.00%

    The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.

  • GC39415 structure
    GC39415OR-1896
    CAS: 220246-81-1
    纯度: >98.50%

    OR-1896 是 Levosimendan 的活性长寿代谢产物。OR-1896 是一种高选择性磷酸二酯酶 (PDE III) 抑制剂，是一种功能强大的血管扩张剂。OR-1896 可以打开 ATP 敏感的 K+ 通道，并具有 Ca2+ 致敏作用。OR-1896 可减轻心肌细胞的凋亡，心脏重塑和心肌炎症。

  • GC39418 structure
    GC39418p-Anisic acid
    CAS: 100-09-4
    纯度: >99.50%

    p-Anisic acid (4-Methoxybenzoic acid) 是anisic acid 的一个异构体，具有抗菌和防腐活性。