GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC38837 structure
    GC38837Prinomastat hydrochloride
    CAS: 1435779-45-5
    纯度: >98.00%

    An inhibitor of MMP-2, -3, -9, -13, and -14

  • GC38856 structure
    GC38856TD-0212 TFA
    CAS: 1073549-11-7
    纯度: >98.00%

    TD-0212 TFA 是一种具有口服活性的、血管紧张素II型1受体AT1 和脑啡肽酶 (NEP)的双抑制剂，其对AT1的pKi值为 8.9， 对NEP 的pIC50值为9.2。

  • GC38859 structure
    GC38859Tetrahydrocortisone
    CAS: 53-05-4
    纯度: >98.00%

    A metabolite of cortisol

  • GC38871 structure
    GC38871XL-784 free base
    CAS: 1356992-21-6

    XL-784 free base 是 MMP 的一个选择性抑制剂，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13 的 IC50 值分别约为 1900，0.81，120，10.8，18，0.56 nM。

  • GC38881 structure
    GC3888110,12-Tricosadiynoic acid
    CAS: 66990-30-5
    纯度: >99.00%

    10,12-Tricosadiynoic acid是一种具有高效特异性、选择性和口服活性的酰基辅酶A氧化酶-1（ACOX1）抑制剂。

  • GC38882 structure
    GC388825-ALA benzyl ester hydrochloride
    CAS: 163271-32-7
    纯度: >97.50%

    5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种用作光检测器的原卟啉前体。5-ALA benzyl ester hydrochloride 诱导原卟啉 IX (PPIX) 在结肠癌细胞系中的积聚。

  • GC38883 structure
    GC388839-Ethyladenine
    CAS: 2715-68-6

    9-Ethyladenine 是 APRT (腺嘌呤磷酸核糖基转移酶) 的部分有效抑制剂。

  • GC38885 structure
    GC38885alpha-D-glucose
    CAS: 492-62-6
    纯度: >99.00%

    Alpha-D-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is an intermediate in glycolysis/gluconeogenesis pathway.

  • GC38903 structure
    GC38903Deslanoside
    CAS: 17598-65-1
    纯度: >98.00%

    A cardiac glycoside

  • GC38909 structure
    GC38909EN40
    CAS: 2094547-67-6

    EN40 是一种有效的选择性乙醛脱氢酶 3A1 (ALDH3A1) 抑制剂，一种共价配体，IC50 值为 2 uM。

  • GC38920 structure
    GC38920L-Carnitine hydrochloride
    CAS: 6645-46-1
    纯度: >98.00%

    L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.

  • GC38929 structure
    GC38929MMP-9-IN-1
    CAS: 502887-71-0
    纯度: >98.00%

    MMP-9-IN-1是基质金属蛋白酶-9（MMP-9）的特异性抑制剂。它通过选择性靶向MMP-9的血浆铜蓝蛋白（PEX）结构域发挥作用，Kd值为2.1μM。

  • GC38931 structure
    GC38931N-Desmethyltamoxifen hydrochloride
    CAS: 15917-65-4
    纯度: >99.50%

    N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 ?M.

  • GC38958 structure
    GC38958Sorbic acid
    CAS: 110-44-1
    纯度: >99.50%

    Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).

  • GC38971 structure
    GC38971Toddalolactone
    CAS: 483-90-9
    纯度: >98.00%

    Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.

  • GC39013 structure
    GC39013FPL 62064
    CAS: 103141-09-9
    纯度: >98.00%

    FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.

  • GC39050 structure
    GC39050Prudomestin
    CAS: 3443-28-5

    Prudomestin，从 Prunus domestica 心材中分离得到，具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6?µM)。

  • GC39068 structure
    GC39068Rosamultin
    CAS: 88515-58-6
    纯度: >99.00%

    Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.

  • GC39095 structure
    GC39095Isoliquiritin apioside
    CAS: 120926-46-7
    纯度: >99.50%

    Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

  • GC39115 structure
    GC39115Terpinen-4-ol
    CAS: 562-74-3

    Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties.

  • GC39119 structure
    GC39119Isonicotinic acid
    CAS: 55-22-1
    纯度: >98.00%

    Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.

  • GC39134 structure
    GC39134Isofraxidin
    CAS: 486-21-5
    纯度: >98.00%

    Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.

  • GC39157 structure
    GC39157DS-1001b
    CAS: 1898207-64-1
    纯度: >98.50%

    An inhibitor of mutant IDH1

  • GC39169 structure
    GC39169CC-92480
    CAS: 2259648-80-9
    纯度: >98.00% / >99.00%

    CC-92480（Mezigdomide）是一种新型的Cereblon（CRBN）E3连接酶调节剂（CELMoD），常以分子胶的方式发挥作用，具有增强的肿瘤和免疫调节活性。