GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC38660 structure
    GC38660Megestrol
    CAS: 3562-63-8
    纯度: >99.00%

    Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.

  • GC38669 structure
    GC386693-Hydroxybenzoic acid
    CAS: 99-06-9

    3-Hydroxybenzoic acid 是一种内源性代谢产物。

  • GC38670 structure
    GC386701-Hydroxyoctadecane
    CAS: 112-92-5
    纯度: >98.00%

    1-Hydroxyoctadecane 是一种内源性代谢产物。

  • GC38684 structure
    GC38684(E)-m-Coumaric acid
    CAS: 14755-02-3
    纯度: >99.50%

    3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.

  • GC38688 structure
    GC38688Inosine 5'-monophosphate disodium salt (hydrate)
    CAS: 352195-40-5
    纯度: >99.50%

    Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.

  • GC38689 structure
    GC38689Poly(4-vinylphenol)
    CAS: 24979-70-2
    纯度: >99.00%

    Poly(4-vinylphenol) 是一种内源性代谢产物。

  • GC38690 structure
    GC38690D-Glucuronic acid lactone
    CAS: 32449-92-6
    纯度: >98.00%

    D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis.

  • GC38700 structure
    GC38700D-Arabinose
    CAS: 28697-53-2
    纯度: >98.00%

    A monosaccharide

  • GC38703 structure
    GC38703NSC 8751
    CAS: 107-93-7
    纯度: >99.50%

    NSC 8751 是一种内源性代谢产物。

  • GC38720 structure
    GC38720(R)-Trolox
    CAS: 53101-49-8
    纯度: >98.00%

    (R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。

  • GC38729 structure
    GC387292,5-Dimethylpyrazine
    CAS: 123-32-0
    纯度: >99.50%

    2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite.

  • GC38734 structure
    GC38734Allotetrahydrocortisol
    CAS: 302-91-0
    纯度: >98.00%

    Allotetrahydrocortisol (5a-Tetrahydrocortisol) 是一种皮质醇的代谢产物。Cortisol 是皮质醇是人体主要的糖皮质激素，在肾上腺皮质产生，在许多生理过程中起着至关重要的作用。

  • GC38761 structure
    GC38761Cyclo(his-pro) TFA
    CAS: 936749-56-3
    纯度: >99.00%

    Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) 是一种具有口服活性的，结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) TFA 可以抑制 NF-κB 核积累。Cyclo(his-pro) TFA 可以穿越脑血屏障并影响多种炎症和应激反应。

  • GC38766 structure
    GC38766Delapril hydrochloride
    CAS: 83435-67-0
    纯度: >99.00%

    Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

  • GC38768 structure
    GC38768Deserpidine
    CAS: 131-01-1
    纯度: >98.50%

    Deserpidine (Harmonyl), an alkaloid isolated from the roots of Rauwolfia canescens, is a competitive angiotensin converting enzyme (ACE) inhibitor, also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

  • GC38779 structure
    GC38779Etilevodopa
    CAS: 37178-37-3

    Etilevodopa (L-Dopa ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。

  • GC38782 structure
    GC38782gamma-secretase modulator 1 hydrochloride
    CAS: 2741571-83-3
    纯度: >98.50%

    gamma-secretase inhibitior-1 是 γ-secretase 调节剂，可作用于阿尔茨海默病。

  • GC38807 structure
    GC38807Lapaquistat acetate
    CAS: 189060-13-7
    纯度: >98.00%

    Lapaquistat acetate (TAK-475) 是一种角鲨烯合酶 (squalene synthase) 抑制剂，可阻止法呢基二磷酸酯 (FPP) 转化为角鲨烯。Lapaquistat acetate (TAK-475) 最初旨在用于甲羟戊酸激酶缺乏症 (MKD)，可有效降低低密度脂蛋白胆固醇，但可能引起肝脏损害。

  • GC38809 structure
    GC38809LHVS
    CAS: 170111-28-1
    纯度: >98.00%

    LHVS是一种有效的、非选择性的、不可逆的、可透过细胞的半胱氨酸蛋白酶和组织蛋白酶抑制剂，LHVS还可以抑制 T. gondii （IC 50 =10μM）侵袭。

  • GC38812 structure
    GC38812MD-224
    CAS: 2136247-12-4
    纯度: >98.00% / >99.00%

    MD-224 是一种作用强大的MDM2蛋白降解剂，由Cereblon和MDM2配体组成，能够促使MDM2蛋白迅速降解。

  • GC38815 structure
    GC38815Methyl cinnamate
    CAS: 103-26-4
    纯度: >99.00%

    Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

  • GC38818 structure
    GC38818Mirificin
    CAS: 103654-50-8

    Mirificin (Puerarin apioside) 是葛根中的异黄酮。Mirificin 抑制酪氨酸酶 (TYR)，IC50 为 12.66 μM。

  • GC38831 structure
    GC38831PF-00356231 hydrochloride
    CAS: 820223-77-6
    纯度: >99.50%

    PF-00356231 hydrochloride 是一种非肽、非锌螯合的基质金属蛋白酶 MMP-12 的配体和抑制剂 (IC50=1.4 μM)。它对 MMP-12 具有特异性并形成 PF-00356231/MMP-12 复合体。PF-00356231 hydrochloride 对 MMP-13、MMP-8、MMP-9、MMP-3 有抑制作用，IC50 分别为 0.00065、1.7、0.98、0.39 μM。

  • GC38834 structure
    GC38834Phosphonoacetic acid
    CAS: 4408-78-0
    纯度: >98.00%

    Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.