Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC38370N-Acetyl-L-leucineCAS: 1188-21-2纯度: >99.00%
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
- GC38371(S)-(-)-PhenylethanolCAS: 1445-91-6纯度: >99.50%
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
- GC38382CNDAC hydrochlorideCAS: 134665-72-8纯度: >99.50%
CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。
- GC38438SynephrineCAS: 94-07-5纯度: >98.50%
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
- GC38452Dehydrotrametenolic acidCAS: 6879-05-6纯度: >99.50%
Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性，抗炎，抗糖尿病作用。
- GC38457LapaquistatCAS: 189059-71-0纯度: >99.50%
Lapaquistat (T-91485) 是一种胆固醇生物合成 cholesterol biosynthesis 的抑制剂，是 TAK-475 的活性代谢产物。Lapaquistat 可以降低他汀类药物在降脂治疗中的肌毒性。
- GC38488HinokiflavoneCAS: 19202-36-9纯度: >98.00%
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
- GC38503HSP27 inhibitor J2CAS: 2133499-85-9纯度: >99.00%
HSP27抑制剂J2 (J2)是HSP27的抑制剂,能显著诱导异常HSP27二聚体形成,抑制HSP27大聚合物的生成。
- GC385561-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholineCAS: 76343-22-1纯度: >99.00%
1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 是一种内源性代谢产物。
- GC38593Ethyl glucuronideCAS: 17685-04-0纯度: >98.00%
Ethyl glucuronide是乙醇的一种非挥发性、水溶性的直接代谢物，可在体液、组织和毛发中检测到。
- GC38604Glomeratose ACAS: 202471-84-9纯度: >99.50%
Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。
- GC38654Bis(2-ethylhexyl) phthalateCAS: 117-81-7纯度: >99.00%
Bis(2-ethylhexyl) phthalate，通常称为DEHP，是一种合成化合物，主要用作增塑剂。接触Bis(2-ethylhexyl) phthalate会对生物体产生各种不良影响，如生殖和发育受损、癌症、代谢改变以及神经和行为障碍。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38369 | (±)-Leucine | 328-39-2 | >98.00% | |
(±)-Leucine 是一种内源性代谢产物。 | ||||
| GC38370 | N-Acetyl-L-leucine | 1188-21-2 | >99.00% | |
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. | ||||
| GC38371 | (S)-(-)-Phenylethanol | 1445-91-6 | >99.50% | |
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties. | ||||
| GC38382 | CNDAC hydrochloride | 134665-72-8 | >99.50% | |
CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。 | ||||
| GC38438 | Synephrine | 94-07-5 | >98.50% | |
Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss. | ||||
| GC38440 | Guaiazulene | 489-84-9 | >99.00% | |
A sesquiterpene with diverse biological activities | ||||
| GC38452 | Dehydrotrametenolic acid | 6879-05-6 | >99.50% | |
Dehydrotrametenolic acid 是从茯苓 (Poria cocos) 的菌核中分离的甾醇。Dehydrotrametenolic acid 通过 caspase-3 途径诱导细胞凋亡。Dehydrotrametenolic acid 具有抗肿瘤活性，抗炎，抗糖尿病作用。 | ||||
| GC38457 | Lapaquistat | 189059-71-0 | >99.50% | |
Lapaquistat (T-91485) 是一种胆固醇生物合成 cholesterol biosynthesis 的抑制剂，是 TAK-475 的活性代谢产物。Lapaquistat 可以降低他汀类药物在降脂治疗中的肌毒性。 | ||||
| GC38463 | ASLAN003 | 1035688-66-4 | >99.50% | |
A DHODH inhibitor | ||||
| GC38488 | Hinokiflavone | 19202-36-9 | >98.00% | |
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway. | ||||
| GC38503 | HSP27 inhibitor J2 | 2133499-85-9 | >99.00% | |
HSP27抑制剂J2 (J2)是HSP27的抑制剂,能显著诱导异常HSP27二聚体形成,抑制HSP27大聚合物的生成。 | ||||
| GC38552 | Tetrahydrocortisol | 53-02-1 | >97.00% | |
An endogenous metabolite of cortisol | ||||
| GC38556 | 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine | 76343-22-1 | >99.00% | |
1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine 是一种内源性代谢产物。 | ||||
| GC38560 | Oleoylcarnitine | 38677-66-6 | >96.00% | |
A long-chain acylcarnitine | ||||
| GC38574 | Cholesteryl arachidonate | 604-34-2 | >98.00% | |
A cholesterol ester | ||||
| GC38587 | H-Arg-Lys-OH TFA | - | >98.00% | |
H-Arg-Lys-OH TFA 是由 L-精氨酸和 L-赖氨酸残基形成的二肽。 | ||||
| GC38593 | Ethyl glucuronide | 17685-04-0 | >98.00% | |
Ethyl glucuronide是乙醇的一种非挥发性、水溶性的直接代谢物，可在体液、组织和毛发中检测到。 | ||||
| GC38604 | Glomeratose A | 202471-84-9 | >99.50% | |
Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。 | ||||
| GC38620 | Dihydrorotenone | 6659-45-6 | >98.00% | |
Dihydrorotenone是一种杀虫剂，是线粒体复合物I的不可逆抑制剂，并且能够穿过血脑屏障。 | ||||
| GC38636 | Glabrol | 59870-65-4 | >99.50% | |
Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂，对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。 | ||||
| GC38638 | Euphol | 514-47-6 | >98.00% | |
真酚(Euphol)是Euphorbia tirucalli中的主要成分,真酚可逆的抑制丝氨酸水解酶MGL活性(IC50 = 315 nM)。 | ||||
| GC38640 | IDH889 | 1429179-07-6 | >98.50% | |
IDH889 是一种可口服利用的，脑渗透性的，变构和突变特异性的异柠檬酸脱氢酶 (IDH1) 抑制剂。IDH889 对 IDH1 R132* 突变型具有高效选择性，对 IDH1R132H、IDH1R132C 和 IDH1wt 作用的 IC50 值分别为 0.02 μM, 0.072 μM 和 1.38 μM。IDH889 具有高效的细胞内 2-HG 水平抑制作用，其 IC50 值为 0.014 μM。 | ||||
| GC38644 | Glycodeoxycholic Acid | 360-65-6 | >98.00% | |
Glycodeoxycholic Acid是脱氧胆酸的甘氨酸结合形式。 | ||||
| GC38654 | Bis(2-ethylhexyl) phthalate | 117-81-7 | >99.00% | |
Bis(2-ethylhexyl) phthalate，通常称为DEHP，是一种合成化合物，主要用作增塑剂。接触Bis(2-ethylhexyl) phthalate会对生物体产生各种不良影响，如生殖和发育受损、癌症、代谢改变以及神经和行为障碍。 | ||||