Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC38299(2-Aminoethyl)phosphonic acidCAS: 2041-14-7
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
- GC38300Phytic acid potassiumCAS: 129832-03-7纯度: >98.00%
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
- GC38320L-Methionine sulfoxideCAS: 3226-65-1纯度: >99.50%
L-Methionine sulfoxide (H-Met(O)-OH)，甲硫氨酸的代谢产物，诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。
- GC38323Tetrahydro-2H-pyran-2-oneCAS: 542-28-9纯度: >99.50%
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite.
- GC38327Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrateCAS: 1637-73-6纯度: >97.00%
Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate是三羧酸循环（TCA Cycle）中的关键中间产物，能够作为反应底物测定Isocitrate Dehydrogenase的活性
- GC38356Imidazoleacetic acid hydrochlorideCAS: 3251-69-2纯度: >99.00%
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.
- GC383591H-pyrazoleCAS: 288-13-1
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
- GC383603-Methylbut-2-enoic acidCAS: 541-47-9
Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria.
- GC38363(R)-pyrrolidine-2-carboxylic acidCAS: 344-25-2
D-proline is an isomer of the naturally occurring amino acid, L-Proline.
- GC383672,4-Dihydroxypyrimidine-5-carboxylic AcidCAS: 23945-44-0
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite.
- GC383683-Furanoic acidCAS: 488-93-7纯度: >98.00%
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38297 | 3-Methylindolin-2-one | 1504-06-9 | >98.00% | |
3-Methylindolin-2-one 是一种内源性代谢产物。 | ||||
| GC38298 | Pteridine-2,4(1H,3H)-dione | 487-21-8 | >99.50% | |
Pteridine-2,4(1H,3H)-dione 是一种内源性代谢产物。 | ||||
| GC38299 | (2-Aminoethyl)phosphonic acid | 2041-14-7 | - | |
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages. | ||||
| GC38300 | Phytic acid potassium | 129832-03-7 | >98.00% | |
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM. | ||||
| GC38301 | 2-(1H-Indol-3-yl)ethan-1-ol | 526-55-6 | - | |
An indole with diverse biological activities | ||||
| GC38317 | Acetamide | 60-35-5 | - | |
Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent. | ||||
| GC38320 | L-Methionine sulfoxide | 3226-65-1 | >99.50% | |
L-Methionine sulfoxide (H-Met(O)-OH)，甲硫氨酸的代谢产物，诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。 | ||||
| GC38321 | 2-Aminopyrimidin-5-ol | 143489-45-6 | >99.00% | |
2-Aminopyrimidin-5-ol 是一种内源性代谢产物。 | ||||
| GC38323 | Tetrahydro-2H-pyran-2-one | 542-28-9 | >99.50% | |
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite. | ||||
| GC38324 | D-Galacturonic acid (hydrate) | 91510-62-2 | >98.00% | |
A monosaccharide | ||||
| GC38325 | N-Acetyl-D-mannosamine monohydrate | 7772-94-3 | - | |
A precusor of sialic acid | ||||
| GC38326 | NSC 13138 | 486-74-8 | >98.00% | |
Quinoline-4-carboxylic acid (4-Carboxyquinoline) is a very important structure in a synthetic medicinal chemistry. | ||||
| GC38327 | Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate | 1637-73-6 | >97.00% | |
Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate是三羧酸循环（TCA Cycle）中的关键中间产物，能够作为反应底物测定Isocitrate Dehydrogenase的活性 | ||||
| GC38332 | Ximelagatran | 192939-46-1 | >98.00% | |
A prodrug of melagatran, a thrombin inhibitor | ||||
| GC38356 | Imidazoleacetic acid hydrochloride | 3251-69-2 | >99.00% | |
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. | ||||
| GC38358 | 5'-Cytidylic acid | 63-37-6 | - | |
A pyrimidine nucleotide | ||||
| GC38359 | 1H-pyrazole | 288-13-1 | - | |
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents. | ||||
| GC38360 | 3-Methylbut-2-enoic acid | 541-47-9 | - | |
Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria. | ||||
| GC38362 | KSD 2405 | 620-24-6 | >98.00% | |
3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals. | ||||
| GC38363 | (R)-pyrrolidine-2-carboxylic acid | 344-25-2 | - | |
D-proline is an isomer of the naturally occurring amino acid, L-Proline. | ||||
| GC38364 | (R)-Ornithine hydrochloride | 16682-12-5 | >98.00% | |
An enantiomer of L-ornithine | ||||
| GC38366 | Pyridoxylamine dihydrochloride | 524-36-7 | >99.50% | |
A 4-methylamine form of vitamin B 6 | ||||
| GC38367 | 2,4-Dihydroxypyrimidine-5-carboxylic Acid | 23945-44-0 | - | |
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite. | ||||
| GC38368 | 3-Furanoic acid | 488-93-7 | >98.00% | |
3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. | ||||