Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC382701-Aminocyclopropane-1-carboxylic acidCAS: 22059-21-8纯度: >98.00%
An NMDA receptor partial agonist
- GC382711-Hydroxy-2-naphthoic acidCAS: 86-48-6纯度: >98.00%
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms.
- GC38272H-Phg(4-OH)-OHCAS: 32462-30-9纯度: >98.00%
A CPT1 inhibitor and prodrug form of 4-hydroxyphenylglyoxylic acid
- GC38273Methyl 2-(1H-indol-3-yl)acetateCAS: 1912-33-0纯度: >99.50%
Methyl 3-indolyacetate is a phytohormone.
- GC382762-Oxosuccinic acidCAS: 328-42-7纯度: >98.00%
2-Oxosuccinic acid（草酰乙酸）是一种α-酮酸，在柠檬酸循环的第一步中草酰乙酸与乙酰辅酶A和水反应形成柠檬酸盐，并在最后一步中通过L-苹果酸的氧化再生。
- GC382812-Hydroxy-2-phenylacetic acidCAS: 90-64-2纯度: >99.50%
2-羟基-2-苯乙酸（(±)-2-羟基-2-苯乙酸）是一种α-羟基羧酸，已广泛用作医药和精细化学品的中间体。
- GC38283(3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-oneCAS: 87-81-0纯度: >98.00%
D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.
- GC38284Glycerophosphoric acid disodium salt hydrateCAS: 154804-51-0纯度: >98.00%
Glycerophosphoric acid disodium salt hydrate 是一种内源性代谢物，是一种磷酸酶抑制剂。
- GC382865,6-Dimethyl-1H-benzo[d]imidazoleCAS: 582-60-5纯度: >99.00%
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor.
- GC38287α-PyridoneCAS: 142-08-5纯度: >98.00% / >97.00% / >96.00%
2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis.
- GC382933-Amino-4-hydroxybenzoic acidCAS: 1571-72-8纯度: >97.00%
3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid.
- GC38295N-Acetyl-DL-methionineCAS: 1115-47-5
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
- GC38296(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochlorideCAS: 5505-63-5
An amino monosaccharide
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38270 | 1-Aminocyclopropane-1-carboxylic acid | 22059-21-8 | >98.00% | |
An NMDA receptor partial agonist | ||||
| GC38271 | 1-Hydroxy-2-naphthoic acid | 86-48-6 | >98.00% | |
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. | ||||
| GC38272 | H-Phg(4-OH)-OH | 32462-30-9 | >98.00% | |
A CPT1 inhibitor and prodrug form of 4-hydroxyphenylglyoxylic acid | ||||
| GC38273 | Methyl 2-(1H-indol-3-yl)acetate | 1912-33-0 | >99.50% | |
Methyl 3-indolyacetate is a phytohormone. | ||||
| GC38274 | Oxalic acid dihydrate | 6153-56-6 | >99.00% | |
Oxalic acid dihydrate 是一种内源性代谢产物。 | ||||
| GC38275 | Purine | 120-73-0 | >98.00% | |
An aromatic heterocyclic organic compound | ||||
| GC38276 | 2-Oxosuccinic acid | 328-42-7 | >98.00% | |
2-Oxosuccinic acid（草酰乙酸）是一种α-酮酸，在柠檬酸循环的第一步中草酰乙酸与乙酰辅酶A和水反应形成柠檬酸盐，并在最后一步中通过L-苹果酸的氧化再生。 | ||||
| GC38277 | trans-Cyclohexane-1,2-diol | 1460-57-7 | >95.00% | |
trans-Cyclohexane-1,2-diol 是一种内源性代谢产物。 | ||||
| GC38281 | 2-Hydroxy-2-phenylacetic acid | 90-64-2 | >99.50% | |
2-羟基-2-苯乙酸（(±)-2-羟基-2-苯乙酸）是一种α-羟基羧酸，已广泛用作医药和精细化学品的中间体。 | ||||
| GC38282 | (R)-5-Oxopyrrolidine-2-carboxylic acid | 4042-36-8 | >98.00% | |
A metabolite of D-glutamate | ||||
| GC38283 | (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one | 87-81-0 | >98.00% | |
D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy. | ||||
| GC38284 | Glycerophosphoric acid disodium salt hydrate | 154804-51-0 | >98.00% | |
Glycerophosphoric acid disodium salt hydrate 是一种内源性代谢物，是一种磷酸酶抑制剂。 | ||||
| GC38285 | Flavonol | 577-85-5 | >95.00% / >99.50% | |
A synthetic flavonol | ||||
| GC38286 | 5,6-Dimethyl-1H-benzo[d]imidazole | 582-60-5 | >99.00% | |
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor. | ||||
| GC38287 | α-Pyridone | 142-08-5 | >98.00% / >97.00% / >96.00% | |
2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis. | ||||
| GC38288 | Maleimide | 541-59-3 | >99.00% | |
Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research. | ||||
| GC38289 | N-Methylmethanamine hydrochloride | 506-59-2 | - | |
N-Methylmethanamine hydrochloride 是一种内源性代谢产物。 | ||||
| GC38290 | NSC 45699 | 2018-61-3 | >98.00% | |
A metabolite of L-phenylalanine | ||||
| GC38291 | Indole | 120-72-9 | >99.50% | |
Indole (2,3-Benzopyrrole) is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria. | ||||
| GC38292 | H-Trp-NH2.HCl | 5022-65-1 | >95.00% | |
An endogenous metabolite of L-tryptophan | ||||
| GC38293 | 3-Amino-4-hydroxybenzoic acid | 1571-72-8 | >97.00% | |
3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid. | ||||
| GC38294 | Heptadecanoic acid | 506-12-7 | - | |
An odd-chain saturated fatty acid | ||||
| GC38295 | N-Acetyl-DL-methionine | 1115-47-5 | - | |
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice. | ||||
| GC38296 | (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride | 5505-63-5 | - | |
An amino monosaccharide | ||||