L-Tryptophanamide is an endogenous metabolite of L-tryptophan .1 It inhibits proliferation of, and induces necrosis in, human retinal pigment epithelium cells (HRPECs). Levels of L-tryptophanamide are increased in patients with wet age-related macular degeneration (wAMD) presenting with choroidal neovascularization compared with wAMD patients presenting with polypoidal choroidal neovascularization.
1.Deng, Y., Shuai, P., Wang, H., et al.Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degenerationAging (Albany NY)13(10)13968-14000(2021)