GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC38143 structure
    GC38143Batilol
    CAS: 544-62-7
    纯度: >98.00%

    Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.

  • GC38156 structure
    GC38156ZM223 hydrochloride
    纯度: >98.50%

    ZM223 hydrochloride 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂，具有口服活性。

  • GC38166 structure
    GC38166Trifolirhizin
    CAS: 6807-83-6
    纯度: >99.50% / >98.50%

    A flavonoid with anticancer and vasorelaxant activities

  • GC38178 structure
    GC38178D-Methionine sulfoxide
    CAS: 21056-56-4
    纯度: >98.00%

    D-methionine sulfoxide 是 Methionine sulfoxide 的 D 型异构体。Methionine sulfoxide 是 Methionine 的氧化产物。Methionine 是牛奶或豆类蛋白中的限制性氨基酸，在储存或加工过程中易被氧化。

  • GC38190 structure
    GC381902-Hydroxyhexanoic acid
    CAS: 6064-63-7
    纯度: >98.00%

    2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) is an endogenous metabolite.

  • GC38191 structure
    GC381912'-Deoxyguanosine monohydrate
    CAS: 312693-72-4
    纯度: >97.00%

    A purine nucleoside with diverse biological activities

  • GC38205 structure
    GC38205cis-​9,​10-​Epoxystearic acid
    CAS: 24560-98-3
    纯度: >98.00%

    An epoxy fatty acid

  • GC38223 structure
    GC38223Dihydroberberine
    CAS: 483-15-8
    纯度: >98.00%

    Dihydroberberine是一种强效的haematopoietic prostaglandin D2 synthase (H-PGDS)抑制剂，IC 50 值为3.7μM。

  • GC38235 structure
    GC38235Cuminaldehyde
    CAS: 122-03-2
    纯度: >99.00%

    4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal), a natural organic compound, is a kind of pharmaceutical intermediate with a pleasant smell and contributes to the aroma of essential oils.

  • GC38242 structure
    GC382421,4-Dioxane-2,5-diol
    CAS: 23147-58-2
    纯度: >95.00%

    Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS).

  • GC38243 structure
    GC382432,3-Diaminopropanoic acid hydrochloride
    CAS: 54897-59-5
    纯度: >98.00%

    DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite.

  • GC38246 structure
    GC38246Undecanoic acid
    CAS: 112-37-8
    纯度: >99.50%

    An eleven carbon SFA

  • GC38248 structure
    GC38248Oxalic Acid
    CAS: 144-62-7

    Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.

  • GC38249 structure
    GC38249D-Glucuronic acid
    CAS: 6556-12-3

    A metabolite of glucose

  • GC38257 structure
    GC382573-Ethoxy-3-oxopropanoic acid
    CAS: 1071-46-1
    纯度: >97.00%

    Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP).

  • GC38258 structure
    GC382582'-Deoxyadenosine-5'-monophosphate
    CAS: 653-63-4
    纯度: >95.00%

    A deoxynucleotide

  • GC38259 structure
    GC38259H-D-cis-Hyp-OH
    CAS: 2584-71-6
    纯度: >98.00%

    cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase.

  • GC38260 structure
    GC382602-Aminobenzenesulfonic acid
    CAS: 88-21-1
    纯度: >99.00%

    2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.

  • GC38261 structure
    GC38261H-allo-Thr-OH
    CAS: 28954-12-3
    纯度: >98.00%

    H-allo-Thr-OH 是一种内源性代谢产物。

  • GC38262 structure
    GC38262(R)-(-)-1,3-Butanediol
    CAS: 6290-03-5

    (R)-(-)-1,3-Butanediol 可以用于调节糖类脂类代谢。

  • GC38264 structure
    GC38264Ac-Ala-OH
    CAS: 97-69-8
    纯度: >98.00%

    N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.

  • GC38265 structure
    GC38265(2R,3R)-2,3-Dihydroxysuccinic acid
    CAS: 87-69-4
    纯度: >98.00%

    Tartaric acid (2,3-Dihydroxysuccinic acid, Threaric acid, Racemic acid, Uvic acid, Paratartaric acid, Winestone) is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use.

  • GC38266 structure
    GC38266Quinoline-2-carboxylic acid
    CAS: 93-10-7
    纯度: >99.00%

    Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine.

  • GC38268 structure
    GC38268Indole-3-acetamide
    CAS: 879-37-8
    纯度: >98.00%

    Indole-3-acetamide是吲哚-3-乙酸的生物合成中间体。