2'-Deoxyguanosine is a purine nucleoside with diverse biological activities.1,2,3,4 It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 ?M, respectively).1 2'-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 ?M.2 It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems.3 2'-Deoxyguanosine (>1 ?M) also induces relaxation of precontracted isolated bovine lingual artery.4
1.Ross, D.D., Akman, S.A., Schrecker, A.W., et al.Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide poolsCancer Res.41(11 Pt 1)4493-4498(1981) 2.Mitchell, B.S., Mejias, E., Daddona, P.E., et al.Purinogenic immunodeficiency diseases: Selective toxicity of deoxyribonucleosides for T cellsProc. Natl. Acad. Sci. USA75(10)5011-5014(1978) 3.Brulfert, A., Clain, E., and Deysson, G.Deoxyguanosine, a potent cytokinesis inhibitor in plant cellsExperientia30(9)1010-1011(1974) 4.Scholar, E.M.Effect of deoxypurine and deoxypyrimidine compounds on the vascular responsiveness of bovine coronary and lingual arteriesJ. Pharm. Pharmacol.32(10)726(1980)