2'-Deoxyadenosine-5'-monophosphate

2’-Deoxyadenosine-5'-monophosphate is a derivative of the nucleic acid, AMP, in which the hydroxyl group on the 2' carbon of the pentose has been reduced to a hydrogen atom. It has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.^1,2,3

1.Zofall, M., and Bartholomew, B.Two novel dATP analogs for DNA photoaffinity labelingNucleic Acids Res.28(21)4382-4390(2000) 2.Li, Y.M., Han, Z.H., Jiang, S.H., et al.Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis HemslActa Pharmacol. Sin.21(12)1125-1128(2000) 3.Duarte, V., Muller, J.G., and Burrows, C.J.Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanineNucleic Acids Res.27(2)496-502(1999)