GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC37755 structure
    GC37755LX1606 (Telotristat ethyl)
    CAS: 1033805-22-9
    纯度: >99.00%

    LX1606 (Telotristat ethyl) (LX1032) 是一种新型的口服色氨酸羟化酶抑制剂，可减少血清素的产生。

  • GC37757 structure
    GC37757Teneligliptin hydrobromide hydrate
    CAS: 1572583-29-9

    A DPP-4 inhibitor

  • GC37780 structure
    GC37780Thevetiaflavone
    CAS: 29376-68-9

    Thevetiaflavone 可以上调 Bcl?2 的表达，下调 Bax 和 caspase-3 的表达。

  • GC37790 structure
    GC37790Tiglic acid
    CAS: 80-59-1
    纯度: >99.50%

    Tiglic acid (Cevadic acid, Sabadillic acid, Tiglinic acid) is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. It is used in making perfumes and flavoring agents.

  • GC37820 structure
    GC37820Trans (2,3)-Dihydrotetrabenazine
    CAS: 171598-74-6

    Trans (2,3)-Dihydrotetrabenazine， 是抗精神病药物Tetrabenazine的体内代谢物，能够抑制囊泡单胺转运体 2 (VMAT2)。

  • GC37826 structure
    GC37826Tricaprilin
    CAS: 538-23-8
    纯度: >98.00%

    A triacylglycerol

  • GC37830 structure
    GC37830Trimethoprim 3-oxide
    CAS: 27653-67-4

    Trimethoprim 3-oxide 为一种三甲氧苄二氨嘧啶的初级代谢物。

  • GC37864 structure
    GC37864Uridine 5'-monophosphate
    CAS: 58-97-9
    纯度: >98.00%

    A ribonucleotide

  • GC37866 structure
    GC37866Uridine diphosphate glucose
    CAS: 133-89-1
    纯度: >99.00%

    尿苷二磷酸葡萄糖（尿嘧啶二磷酸葡萄糖，UDPG）是一种核苷酸糖。

  • GC37902 structure
    GC37902Vicenin 2
    CAS: 23666-13-9
    纯度: >98.00%

    Vicenin 2是一种具有口服活性的血管紧张素转换酶（ACE）抑制剂，IC 50 值为43.83±3.01μM。

  • GC37903 structure
    GC37903Vicenin 3
    CAS: 59914-91-9
    纯度: >98.00%

    Vicenin 3 来自广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 3 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50 为 46.91 μM。

  • GC37921 structure
    GC37921Voxilaprevir
    CAS: 1535212-07-7
    纯度: >99.50%

    A pan-genotypic HCV NS3/4A protease inhibitor

  • GC37942 structure
    GC37942Xanthosine
    CAS: 146-80-5

    Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP.

  • GC37963 structure
    GC37963ZED-1227
    CAS: 1542132-88-6
    纯度: >99.50%

    ZED-1227 是一种特异性的、口服的转谷氨酰胺酶 2 (TG2) 抑制剂，能阻塞炎症诱导的 TG2 表达和激活，有作为治疗乳糜泻药物的前景。

  • GC37972 structure
    GC37972Zofenopril
    CAS: 81872-10-8

    A prodrug form of zofenoprilat

  • GC37974 structure
    GC37974ZYZ-488
    CAS: 1470302-79-4
    纯度: >99.50%

    ZYZ-488 是一种竞争性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制结合蛋白 procaspase-9 和 procaspase-3 的激活。

  • GC38000 structure
    GC38000β-Boswellic acid
    CAS: 631-69-6
    纯度: >98.50%

    A pentacyclic triterpene with diverse bioactivities

  • GC38010 structure
    GC38010γ-Aminobutyric acid
    CAS: 56-12-2
    纯度: >99.00%

    γ-氨基丁酸（γ-Aminobutyric acid，GABA）是成人大脑中的主要抑制性神经递质。

  • GC38011 structure
    GC38011γ-Secretase modulator 4
    CAS: 1420200-82-3

    γ-Secretase modulator 4 是一种有效的 γ- 分泌酶调节剂 (γ-secretase)，在人类和小鼠中降低 Aβ42 产生的 IC50 值分别为 0.014 μM 和 0.017 μM。

  • GC38012 structure
    GC38012JBSNF-000088
    CAS: 7150-23-4
    纯度: >98.00%

    An inhibitor of NNMT

  • GC38028 structure
    GC38028PF-06446846 hydrochloride
    CAS: 1632250-50-0
    纯度: >98.00%

    PF-06446846 hydrochloride具有口服活性的前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK9）翻译抑制剂。

  • GC38058 structure
    GC380585-Methoxy-DL-tryptophan
    CAS: 28052-84-8
    纯度: >99.00%

    An active metabolite of tryptophan

  • GC38116 structure
    GC38116Purpurogallin
    CAS: 569-77-7
    纯度: >96.00% / >98.00%

    A phenol

  • GC38136 structure
    GC38136m-Tyramine hydrobromide
    CAS: 38449-59-1
    纯度: >98.50%

    m-Tyramine hydrobromide 是一种内源性微量胺神经调节剂。m-Tyramine hydrobromide 对肾上腺素能 (adrenergic) 和多巴胺能受体 (dopaminergic) 有影响。