Pyridoxylamine is a 4-methylamine form of vitamin B6 that is converted to pyridoxal 5'-phosphate , the active form of vitamin B6, and an important cofactor for metabolism.1 It scavenges isoketals in cell-free assays and inhibits the formation of lysyl-levuglandin-lactam adducts in dazoxiben-stimulated isolated human platelets when used at concentrations of 0.1 and 1 mM.2 Pyridoxylamine (1 g/L in the drinking water) inhibits the development of acellular capillaries and accumulation of Nε-(1-carboxymethyl)-L-lysine in the retina in a rat model of diabetes induced by streptozotocin .3 It reverses STZ-induced deficits in the novel object recognition task in a rat model of diabetes when administered in the drinking water at concentrations of 0.4 and 1 g/L.4
1.Kohlmeier, M.Water-soluble vitamins and nonnutrientsNutrient metabolism567-671(2015) 2.Davies, S.S., Brantley, E.J., Voziyan, P.A., et al.Pyridoxylamine analogues scavenge lipid-derived γ-ketoaldehydes and protect against H2O2-mediated cytotoxicityBiochemistry45(51)(2006) 3.Stitt, A., Gardiner, T.A., Alderson, N.L., et al.The AGE inhibitor Pyridoxylamine inhibits development of retinopathy in experimental diabetesDiabetes51(9)2826-2832(2002) 4.Kassab, S., Begley, P., Church, S.J., et al.Cognitive dysfunction in diabetic rats is prevented by Pyridoxylamine treatment. A multidisciplinary investigationMol. Metab.28107-119(2019)