Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC72712Z-FG-NHO-BzOMECAS: 180313-86-4纯度: >98.00%
Z-FG-NHO-BzOME是一种半胱氨酸蛋白酶抑制剂,选择性抑制组织蛋白酶B、组织蛋白酶L、组织蛋白酶S和木瓜蛋白酶。
- GC72732Trimethylammonium chloride-d6CAS: 347840-14-6纯度: 不显示
Trimethylammonium chloride-d6是氘标记的三甲基氯化铵。
- GC72762Adenosine 5′-diphosphoriboseCAS: 20762-30-5纯度: >98.00%
Adenosine 5′-diphosphoribose(ADP核糖)由连接到核糖糖的腺嘌呤碱基组成,核糖糖又连接到两个磷酸基团。
- GC72822Zelavespib hydrochlorideCAS: 2095432-24-7纯度: >98.00%
Zelavespib hydrochloride(PU-H71)是一种强效的Hsp90抑制剂,在MDA-MB-468细胞中的IC50为51 nM。
- GC72823Zelavespib formic纯度: >97.00%
Zelavespib formic (PU-H71 formic)是一种有效的Hsp90抑制剂,在MDA-MB-468细胞中对Hsp90的IC50值为51 nM。
- GC72837α-Hydroxyglutaric acid-d4 disodiumCAS: 2483831-91-8纯度: >: .00%
α-Hydroxyglutaric acid-d4 disodium为氘标记的α-羟基戊二酸二钠。
- GC728381-Methyladenosine-d3 hydrochloride纯度: 不显示
1-Methyladenosine-d3 hydrochloride是氘的氯盐形式,标记为1-甲基腺苷。
- GC72840Isocitric acidCAS: 320-77-4纯度: >99.50% / >99.00%
Isocitric acid是一种存在于唾液和细胞质中的内源性代谢物,可用于阿尔茨海默病、路易体痴呆和缺氧的研究。
- GC72878UCD38B hydrochlorideCAS: 1115177-19-9纯度: >99.00%
UCD38B hydrochloride是一种细胞渗透的竞争性酶促uPA抑制剂,IC50值为7 μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC72702 | Mergetpa | 77102-28-4 | >95.00% | |
Mergetpa是一种羧肽酶抑制剂,用于阻断激肽和B2受体拮抗剂转化为缺乏C末端精氨酸的代谢物。 | ||||
| GC72712 | Z-FG-NHO-BzOME | 180313-86-4 | >98.00% | |
Z-FG-NHO-BzOME是一种半胱氨酸蛋白酶抑制剂,选择性抑制组织蛋白酶B、组织蛋白酶L、组织蛋白酶S和木瓜蛋白酶。 | ||||
| GC72719 | L-Proline-d7 | 39063-89-3 | >99.00% | |
L-Proline-d7是氘标记的L-脯氨酸。 | ||||
| GC72725 | L-Cysteine-3-13C | 201612-57-9 | >99.00% | |
L-Cysteine-3-13C是13C标记的L-半胱氨酸。 | ||||
| GC72726 | L-Cysteine-13C3 | 202114-66-7 | >99.50% | |
L-Cysteine-13C3是13C标记的L-半胱氨酸。 | ||||
| GC72727 | L-Cysteine-d3 | 214782-32-8 | >99.00% | |
L-Cysteine-d3是氘标记的L-半胱氨酸。 | ||||
| GC72732 | Trimethylammonium chloride-d6 | 347840-14-6 | 不显示 | |
Trimethylammonium chloride-d6是氘标记的三甲基氯化铵。 | ||||
| GC72733 | Itaconic acid-13C5 | 2095777-38-9 | >97.00% | |
Itaconic acid-13C5是13C标记的衣康酸。 | ||||
| GC72737 | Levulinic acid-d5 | 1206185-52-5 | 不显示 | |
Levulinic acid-d5是氘标记的乙酰丙酸。 | ||||
| GC72746 | Hydrocinnamic acid-d9 | 93131-15-8 | >99.00% | |
Hydrocinnamic acid-d9是氘标记的氢化肉桂酸。 | ||||
| GC72761 | Sulodexide | 57821-29-1 | 不显示 | |
Sulodexide是由低分子量肝素(80%)和硫酸皮肤素(20%)组成的糖胺聚糖的口服活性混合物。 | ||||
| GC72762 | Adenosine 5′-diphosphoribose | 20762-30-5 | >98.00% | |
Adenosine 5′-diphosphoribose(ADP核糖)由连接到核糖糖的腺嘌呤碱基组成,核糖糖又连接到两个磷酸基团。 | ||||
| GC72788 | HLF1-11 | 183623-03-2 | >99.00% | |
HLF1-11人乳铁蛋白衍生肽是一种广谱抗菌剂。 | ||||
| GC72794 | Flobufen | 112344-52-2 | 不显示 | |
Flobufen(VUFB 16066)是一种非甾体抗炎药和环氧化酶(COX)和5-脂氧合酶(5-LOX)抑制剂。 | ||||
| GC72803 | Aspidin BB | 584-28-1 | >98.00% | |
Aspidin BB是一种间苯三酚衍生物,可从冠毛鳞毛蕨的地上部分分离得到。 | ||||
| GC72822 | Zelavespib hydrochloride | 2095432-24-7 | >98.00% | |
Zelavespib hydrochloride(PU-H71)是一种强效的Hsp90抑制剂,在MDA-MB-468细胞中的IC50为51 nM。 | ||||
| GC72823 | Zelavespib formic | - | >97.00% | |
Zelavespib formic (PU-H71 formic)是一种有效的Hsp90抑制剂,在MDA-MB-468细胞中对Hsp90的IC50值为51 nM。 | ||||
| GC72832 | (1R)-IDH889 | 1429179-08-7 | 不显示 | |
(1R)-IDH889是IDH889的异构体并且可以用作实验对照。 | ||||
| GC72837 | α-Hydroxyglutaric acid-d4 disodium | 2483831-91-8 | >: .00% | |
α-Hydroxyglutaric acid-d4 disodium为氘标记的α-羟基戊二酸二钠。 | ||||
| GC72838 | 1-Methyladenosine-d3 hydrochloride | - | 不显示 | |
1-Methyladenosine-d3 hydrochloride是氘的氯盐形式,标记为1-甲基腺苷。 | ||||
| GC72840 | Isocitric acid | 320-77-4 | >99.50% / >99.00% | |
Isocitric acid是一种存在于唾液和细胞质中的内源性代谢物,可用于阿尔茨海默病、路易体痴呆和缺氧的研究。 | ||||
| GC72843 | TRIA-662-d3 | 1218993-18-0 | >99.00% | |
TRIA-662-d3是氘标记TRIA-662。 | ||||
| GC72878 | UCD38B hydrochloride | 1115177-19-9 | >99.00% | |
UCD38B hydrochloride是一种细胞渗透的竞争性酶促uPA抑制剂,IC50值为7 μM。 | ||||
| GC72916 | Biguanide | 56-03-1 | >98.00% | |
Biguanide是一种口服活性降糖剂。 | ||||
