Zelavespib hydrochloride

目录号: GC72822纯度: >98.00%同义词: PU-H71 hydrochloride
Zelavespib hydrochloride(PU-H71)是一种强效的Hsp90抑制剂,在MDA-MB-468细胞中的IC50为51 nM。

Zelavespib hydrochloride
Cas No.: 2095432-24-7
规格价格库存数量操作
5 mg¥444.00现货
1
10 mg¥711.00现货
1
25 mg¥1,575.00现货
1
50 mg¥2,700.00现货
1
100 mg¥4,590.00现货
1
10mM (in 1mL Water)¥782.00现货
1

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产品描述 Description

Zelavespib (PU-H71) drochloride is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.


References:
[1]. Caldas-Lopes E, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73.
[2]. Guo A, et al. HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment. Oncogene. 2017 Jun 15;36(24):3441-3449.
[3]. Qu Z, et al. PU-H71 effectively induces degradation of IκB kinase β in the presence of TNF-α. Mol Cell Biochem. 2014 Jan;386(1-2):135-42.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2095432-24-7
同义词
PU-H71 hydrochloride
分子式
C18H22ClIN6O2S
分子量
548.83 g/mol
溶解性
H<sub>2</sub>O : 15.38 mg/mL (28.02 mM; Need ultrasonic)
保存条件
4&#176;C, sealed storage, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol