Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC720637,8,3′,4′-TetrahydroxyflavoneCAS: 3440-24-2纯度: >99.00%
7,8,3′,4′-Tetrahydroxyflavone（化合物2）是一种强效的黄嘌呤氧化酶（XOD）抑制剂，IC50值为10.488µM。
- GC72075Mevalonic acid 5-pyrophosphate tetralithiumCAS: 108869-00-7纯度: >93.00%
Mevalonic acid 5-pyrophosphate tetralithium是甲羟戊酸途径的内源性代谢产物。
- GC72158Alanine dehydrogenase, expressed in E. coliCAS: 9029-06-5纯度: 不显示
Alanine dehydrogenase, expressed in E. coli是一种微生物酶，催化l -丙氨酸可逆转化为丙酮酸。
- GC72161Glutamate dehydrogenase (NAD(P))CAS: 9029-12-3纯度: BA-≥400u/mg protein
Glutamate dehydrogenase (NAD(P)) GLDH可在肝细胞、肾组织、脑、肌肉和肠细胞中发现。
- GC72202Mca-PLAQAV-Dpa-RSSSR-NH2 TFA纯度: >99.00%
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA是一种荧光肽，是TNF-α转化酶（TACE）的荧光底物之一；ADAM17、ADAM9和ADAM10。
- GC72241Glutathione diethyl ester TFA纯度: >98.00%
Glutathione diethyl ester TFA是谷胱甘肽单酯的递送剂，因此也是谷胱甘肽在人体细胞中的递送剂。因此，它可以减少氧化应激和毒性。
- GC72371RegdanvimabCAS: 2444308-95-4纯度: 95.00%
Regdanvimab（CT-P59）是一种针对严重急性呼吸系统综合征冠状病毒2型刺突蛋白受体结合结构域的人单克隆抗体，阻断与ACE2的相互作用以进入病毒。
- GC725075-Hydroxyindole-3-acetic acid-d2CAS: 56209-31-5纯度: 不显示
5-Hydroxyindole-3-acetic acid-d2为氘标记的5-羟基吲哚-3-乙酸。
- GC725193-Hydroxybutyric acid-13C4 sodiumCAS: 287111-43-7纯度: 不显示
3-Hydroxybutyric acid-13C4 sodium是13C标记的3-羟基丁酸钠。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC72063 | 7,8,3′,4′-Tetrahydroxyflavone | 3440-24-2 | >99.00% | |
7,8,3′,4′-Tetrahydroxyflavone（化合物2）是一种强效的黄嘌呤氧化酶（XOD）抑制剂，IC50值为10.488µM。 | ||||
| GC72064 | Oleacein | 149183-75-5 | 不显示 | |
Oleacein（化合物9）是一种ACE抑制剂，可以从桔梗中分离出来。 | ||||
| GC72068 | Batatasin IV | 60347-67-3 | 不显示 | |
Batatasin IV是一种具有抗炎活性的LTA4H抑制剂。 | ||||
| GC72074 | Broussoflavonol F | 162558-94-3 | >98.00% | |
Broussoflavonol F具有黄嘌呤氧化酶抑制活性。 | ||||
| GC72075 | Mevalonic acid 5-pyrophosphate tetralithium | 108869-00-7 | >93.00% | |
Mevalonic acid 5-pyrophosphate tetralithium是甲羟戊酸途径的内源性代谢产物。 | ||||
| GC72078 | Azadiradione | 26241-51-0 | 不显示 | |
Azadiradione是在印度印楝中发现的一种生物活性类柠檬素。 | ||||
| GC72140 | Pep2-8 TFA | - | >99.00% | |
Pep2-8 TFA是一种增强subtilin/ keexin 9型蛋白转化酶(PCSK9)拮抗活性的肽。 | ||||
| GC72147 | Mca-YVADAP-Lys(Dnp)-OH TFA | - | >98.00% | |
Mca-YVADAP-Lys(Dnp)-OH TFA是caspase-1和血管紧张素转换酶ACE2的荧光底物。 | ||||
| GC72155 | Chitinase | 9001-06-3 | BA-100.21U/mg solid | |
Chitinase是一种Chitinase，主要存在于芽孢杆菌中，以胶体几丁质为底物。 | ||||
| GC72158 | Alanine dehydrogenase, expressed in E. coli | 9029-06-5 | 不显示 | |
Alanine dehydrogenase, expressed in E. coli是一种微生物酶，催化l -丙氨酸可逆转化为丙酮酸。 | ||||
| GC72161 | Glutamate dehydrogenase (NAD(P)) | 9029-12-3 | BA-≥400u/mg protein | |
Glutamate dehydrogenase (NAD(P)) GLDH可在肝细胞、肾组织、脑、肌肉和肠细胞中发现。 | ||||
| GC72202 | Mca-PLAQAV-Dpa-RSSSR-NH2 TFA | - | >99.00% | |
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA是一种荧光肽，是TNF-α转化酶（TACE）的荧光底物之一；ADAM17、ADAM9和ADAM10。 | ||||
| GC72231 | Hepcidin-1 (mouse) (TFA) | - | >98.00% | |
Hepcidin-1 (mouse) (TFA)是一种参与调节铁稳态的内源性肽激素。 | ||||
| GC72234 | Z-Phe-Arg-pNA | 117761-01-0 | >99.00% | |
Z-Phe-Arg-pNA是组织蛋白酶L的底物。 | ||||
| GC72241 | Glutathione diethyl ester TFA | - | >98.00% | |
Glutathione diethyl ester TFA是谷胱甘肽单酯的递送剂，因此也是谷胱甘肽在人体细胞中的递送剂。因此，它可以减少氧化应激和毒性。 | ||||
| GC72282 | Irucalantide | 1631160-47-8 | >99.00% | |
Irucalantide是激肽释放酶抑制剂。 | ||||
| GC72371 | Regdanvimab | 2444308-95-4 | 95.00% | |
Regdanvimab（CT-P59）是一种针对严重急性呼吸系统综合征冠状病毒2型刺突蛋白受体结合结构域的人单克隆抗体，阻断与ACE2的相互作用以进入病毒。 | ||||
| GC72372 | Etesevimab | 2423948-94-9 | 不显示 | |
Etesevimab（JS016）是一种重组中和人IgG1抗严重急性呼吸系统综合征冠状病毒2型单克隆抗体。 | ||||
| GC72400 | Zampilimab | 2098280-42-1 | >98.00% | |
Zampilimab（UCB-7858）是一种针对转谷氨酰胺酶2（TG2）的单克隆抗体。 | ||||
| GC72483 | Indole-d7 | 73509-20-3 | >99.50% | |
Indole-d7是氘标记的吲哚。 | ||||
| GC72503 | 5-Methylcytosine-d4 | 1219795-15-9 | >99.00% | |
5-Methylcytosine-d4是氘标记的5-甲基胞嘧啶。 | ||||
| GC72507 | 5-Hydroxyindole-3-acetic acid-d2 | 56209-31-5 | 不显示 | |
5-Hydroxyindole-3-acetic acid-d2为氘标记的5-羟基吲哚-3-乙酸。 | ||||
| GC72519 | 3-Hydroxybutyric acid-13C4 sodium | 287111-43-7 | 不显示 | |
3-Hydroxybutyric acid-13C4 sodium是13C标记的3-羟基丁酸钠。 | ||||
| GC72528 | Monobenzyl phthalate-d4 | 478954-83-5 | >99.00% | |
Monobenzyl phthalate-d4是氘标记的邻苯二甲酸一苯酯。 | ||||