Pep2-8 is a peptide which has enhanced the antagonistic activity of proprotein convertase subtilin/ kexin 9 type (PCSK9).
Pep2-8 TFA binds to C-terminally truncated PCSK9[1].
Pep2-8 TFA restored LDL uptake of PCSK9-treated HepG2 cells to about 90% of control activity at a concentration of 50 μM[1].
References:
[1]. Lammi C, et al. Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity. Sci Rep. 2019 Feb 20;9(1):2343.