Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC43400Dehydro Aripiprazole (hydrochloride)CAS: 1008531-60-9纯度: >98.00%
The primary, active metabolite of aripiprazole
- GC43412Desacetyl BisacodylCAS: 603-41-8纯度: >97.00%
An active metabolite of the laxatives bisacodyl and sodium picosulfate
- GC43418Desethylene Ciprofloxacin (hydrochloride)CAS: 528851-31-2纯度: >98.00%
A major metabolite and degradation product of ciprofloxacin
- GC43423Desmethylene Paroxetine (hydrochloride)CAS: 1394861-12-1纯度: >98.00%
A major metabolite of the SSRI paroxetine
- GC43431D-Fructose-6-phosphate (sodium salt)CAS: 26177-86-6纯度: >99.00% / >98.00%
D-Fructose-6-phosphate (sodium salt)是一种内源性代谢物，是糖酵解和磷酸戊糖途径的中间产物。
- GC43432D-Glucosamine-2-sulfate (sodium salt)CAS: 38899-05-7纯度: >95.00%
D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。
- GC43434D-Glucose-6-phosphate (sodium salt)CAS: 54010-71-8纯度: >98.00%
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
- GC43444Diclofenac Acyl-β-D-GlucuronideCAS: 64118-81-6纯度: >95.00%
An active metabolite of diclofenac
- GC43459Dihydro MontelukastCAS: 142147-67-9纯度: >98.00%
A potential impurity found in commercial montelukast preparations
- GC43490DL-Glyceraldehyde-3-phosphateCAS: 591-59-3纯度: >98.00%
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。
- GC43498DL-α-Lipoic AcidCAS: 1077-28-7纯度: >99.00%
An important decarboxylation cofactor and antioxidant
- GC43616EOS (d18:1/32:1/18:2)CAS: 1318771-31-1纯度: >95.00%
An essential ceramide for prevention of epidermal water loss
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC43400 | Dehydro Aripiprazole (hydrochloride) | 1008531-60-9 | >98.00% | |
The primary, active metabolite of aripiprazole | ||||
| GC43401 | Dehydro Nifedipine | 67035-22-7 | >98.00% | |
An active metabolite of nifedipine | ||||
| GC43403 | Dehydroepiandrosterone Sulfate (sodium salt) | 1099-87-2 | >98.00% | |
A steroid precursor | ||||
| GC43412 | Desacetyl Bisacodyl | 603-41-8 | >97.00% | |
An active metabolite of the laxatives bisacodyl and sodium picosulfate | ||||
| GC43418 | Desethylene Ciprofloxacin (hydrochloride) | 528851-31-2 | >98.00% | |
A major metabolite and degradation product of ciprofloxacin | ||||
| GC43419 | Desmethyl Erlotinib | 183321-86-0 | >98.00% | |
A metabolite of erlotinib | ||||
| GC43422 | Desmethyldoxepin (hydrochloride) | 2887-91-4 | >98.00% | |
The primary metabolite of doxepin | ||||
| GC43423 | Desmethylene Paroxetine (hydrochloride) | 1394861-12-1 | >98.00% | |
A major metabolite of the SSRI paroxetine | ||||
| GC43431 | D-Fructose-6-phosphate (sodium salt) | 26177-86-6 | >99.00% / >98.00% | |
D-Fructose-6-phosphate (sodium salt)是一种内源性代谢物，是糖酵解和磷酸戊糖途径的中间产物。 | ||||
| GC43432 | D-Glucosamine-2-sulfate (sodium salt) | 38899-05-7 | >95.00% | |
D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。 | ||||
| GC43434 | D-Glucose-6-phosphate (sodium salt) | 54010-71-8 | >98.00% | |
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。 | ||||
| GC43444 | Diclofenac Acyl-β-D-Glucuronide | 64118-81-6 | >95.00% | |
An active metabolite of diclofenac | ||||
| GC43453 | Diflapolin | 724453-98-9 | >99.00% | |
A dual FLAP/sEH inhibitor | ||||
| GC43459 | Dihydro Montelukast | 142147-67-9 | >98.00% | |
A potential impurity found in commercial montelukast preparations | ||||
| GC43463 | DiIC1(5) | 36536-22-8 | >98.00% | |
DiIC1(5)是一种用于检测线粒体膜电位破坏的信号关闭型荧光探针，激发/发射波长分别为638nm和 675nm。 | ||||
| GC43490 | DL-Glyceraldehyde-3-phosphate | 591-59-3 | >98.00% | |
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。 | ||||
| GC43493 | DL-Sulforaphane N-acetyl-L-cysteine | 334829-66-2 | >98.00% | |
An anticancer agent | ||||
| GC43498 | DL-α-Lipoic Acid | 1077-28-7 | >99.00% | |
An important decarboxylation cofactor and antioxidant | ||||
| GC43543 | DNP-INT | 69311-70-2 | >98.00% | |
An electron transport inhibitor in plants | ||||
| GC43565 | Doxorubicinol (hydrochloride) | 63950-05-0 | >90.00% | |
A doxorubicin metabolite | ||||
| GC43582 | Dynorphin B (1-9) (trifluoroacetate salt) | - | >95.00% | |
A neuropeptide | ||||
| GC43609 | Enniatin A | 2503-13-1 | >99.00% | |
A component of the enniatin complex | ||||
| GC43611 | Enniatin B1 | 19914-20-6 | >99.00% | |
An antibiotic ionophore | ||||
| GC43616 | EOS (d18:1/32:1/18:2) | 1318771-31-1 | >95.00% | |
An essential ceramide for prevention of epidermal water loss | ||||