Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC43225Celecoxib Carboxylic Acid Acyl-β-D-GlucuronideCAS: 264236-79-5纯度: >95.00%
A metabolite of celecoxib
- GC43251Cholesterol Sulfate (sodium salt)CAS: 2864-50-8纯度: >98.00%
硫酸胆固醇（Cholesterol Sulfate (sodium salt)) 于 1965 年首次从人体血浆中分离出来，浓度为 300 μg/100 ml 。
- GC43281Clopidogrel Carboxylic Acid (hydrochloride)CAS: 144750-42-5纯度: >95.00%
A major inactive metabolite of clopidogrel
- GC43284Clozapine N-oxide (hydrochloride)CAS: 2250025-93-3纯度: >98.00%
A metabolite of clozapine and muscarinic DREADD agonist
- GC43295Coenzyme A (sodium salt hydrate)纯度: >95.00%
An essential cofactor in enzymatic acetyl transfer reactions
- GC43297Coenzyme Q2CAS: 606-06-4纯度: >95.00%
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I
- GC43323Creatine Phosphate (potassium salt)CAS: 18838-38-5纯度: >95.00%
磷酸肌酸（钾盐）主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。
- GC43345Cyclohexanoyl Coenzyme ACAS: 5960-12-3纯度: >95.00%
An acyl CoA that contains a cyclohexane group
- GC43355Cytidine 5'-triphosphate (sodium salt)CAS: 36051-68-0纯度: >98.00%
Cytidine 5͇-三磷酸（钠盐）是一种内源性代谢物。
- GC43367D-(+)-Glucose-13C6CAS: 110187-42-3纯度: >99.00% / >98.00%
D-(+)-Glucose-13C6是D-(+)-Glucose的稳定同位素标记对应物，主要用作定量 D-(+)-Glucose的内标，通过GC-或LC-MS测量。
- GC43371Dabigatran Acyl-β-D-GlucuronideCAS: 1015167-40-4纯度: >90.00%
A major active metabolite of dabigatran
- GC43376Dapagliflozin-3-O-β-D-GlucuronideCAS: 1351438-75-9纯度: >95.00%
A metabolite of dapagliflozin
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC43194 | CAY10698 | 684236-01-9 | >98.00% | |
A selective inhibitor of 12-LO | ||||
| GC43195 | CAY10703 | 1841421-67-7 | >95.00% | |
A stable dichloroacetate derivative | ||||
| GC43225 | Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide | 264236-79-5 | >95.00% | |
A metabolite of celecoxib | ||||
| GC43248 | Chlorzoxazone N-Glucuronide | - | >95.00% | |
A phase II metabolite of chlorzoxazone | ||||
| GC43251 | Cholesterol Sulfate (sodium salt) | 2864-50-8 | >98.00% | |
硫酸胆固醇（Cholesterol Sulfate (sodium salt)) 于 1965 年首次从人体血浆中分离出来，浓度为 300 μg/100 ml 。 | ||||
| GC43257 | Cholesteryl Eicosapentaenoate | 74892-97-0 | >99.00% | |
A cholesterol ester | ||||
| GC43261 | Cholesteryl Myristate | 1989-52-2 | >98.00% | |
A cholesterol ester | ||||
| GC43278 | Clindamycin Sulfoxide | 22431-46-5 | >90.00% | |
An active metabolite of clindamycin | ||||
| GC43281 | Clopidogrel Carboxylic Acid (hydrochloride) | 144750-42-5 | >95.00% | |
A major inactive metabolite of clopidogrel | ||||
| GC43284 | Clozapine N-oxide (hydrochloride) | 2250025-93-3 | >98.00% | |
A metabolite of clozapine and muscarinic DREADD agonist | ||||
| GC43285 | CM037 | 896795-60-1 | >98.00% | |
A selective inhibitor of ALDH1A1 | ||||
| GC43289 | Cochlioquinone B | 32450-26-3 | >98.00% | |
A fungal metabolite | ||||
| GC43295 | Coenzyme A (sodium salt hydrate) | - | >95.00% | |
An essential cofactor in enzymatic acetyl transfer reactions | ||||
| GC43296 | Coenzyme B12 | 13870-90-1 | >98.00% | |
A biologically active form of vitamin B 12 | ||||
| GC43297 | Coenzyme Q2 | 606-06-4 | >95.00% | |
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I | ||||
| GC43323 | Creatine Phosphate (potassium salt) | 18838-38-5 | >95.00% | |
磷酸肌酸（钾盐）主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。 | ||||
| GC43343 | Cyclo(L-Tyr-L-Val) | 21754-25-6 | >95.00% | |
A diketopiperazine fungal metabolite | ||||
| GC43345 | Cyclohexanoyl Coenzyme A | 5960-12-3 | >95.00% | |
An acyl CoA that contains a cyclohexane group | ||||
| GC43355 | Cytidine 5'-triphosphate (sodium salt) | 36051-68-0 | >98.00% | |
Cytidine 5͇-三磷酸（钠盐）是一种内源性代谢物。 | ||||
| GC43358 | Cytochalasin A | 14110-64-6 | >98.00% | |
Inhibitor of actin polymerization | ||||
| GC43367 | D-(+)-Glucose-13C6 | 110187-42-3 | >99.00% / >98.00% | |
D-(+)-Glucose-13C6是D-(+)-Glucose的稳定同位素标记对应物，主要用作定量 D-(+)-Glucose的内标，通过GC-或LC-MS测量。 | ||||
| GC43371 | Dabigatran Acyl-β-D-Glucuronide | 1015167-40-4 | >90.00% | |
A major active metabolite of dabigatran | ||||
| GC43376 | Dapagliflozin-3-O-β-D-Glucuronide | 1351438-75-9 | >95.00% | |
A metabolite of dapagliflozin | ||||
| GC43393 | Decanoyl-L-carnitine (chloride) | 369651-88-7 | >98.00% | |
A derivative of L-carnitine | ||||