Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC42915Benzamidine (hydrochloride)CAS: 1670-14-0纯度: >99.00%
Benzamidine (hydrochloride)是一种可逆的、竞争性胰蛋白酶样丝氨酸蛋白酶抑制剂。
- GC43069C22 Ceramide (d18:1/22:0)CAS: 27888-44-4纯度: >95.00% / >98.00%
C22 Ceramide (d18:1/22:0)是一种从海绵 Haliclona koremella 中分离的含有山萮酸的长链神经酰胺，是一种内源性生物活性鞘脂。
- GC43114Caffeic Acid-13C3CAS: 1185245-82-2纯度: >95.00%
An internal standard for the quantification of caffeic acid
- GC43140Captopril DisulfideCAS: 64806-05-9纯度: >95.00%
A metabolite and degradation product of captopril
- GC43141Carboxyatractyloside (potassium salt)CAS: 35988-42-2纯度: >95.00%
An inhibitor of ADP/ATP translocases
- GC43144Carfilzomib Impurity 13 (hydrochloride)CAS: 2319881-95-1纯度: >99.99%
A potential impurity found in commercial carfilzomib preparations
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC42846 | Arachidonoyl-L-carnitine (chloride) | 2133455-98-6 | >95.00% | |
A C20:4 acylcarnitine | ||||
| GC42873 | Auraptene | 495-02-3 | >99.50% | |
A coumarin derivative with anti-inflammatory and chemopreventative activity | ||||
| GC42874 | Aureothin | 2825-00-5 | >96.00% | |
A polyketide antibiotic that inhibits oxidoreductase | ||||
| GC42878 | Avanafil metabolite M16 | 2748151-94-0 | >95.00% | |
A major inactive metabolite of avanafil | ||||
| GC42879 | Avanafil metabolite M4 | - | >98.00% | |
An active metabolite of avanafil | ||||
| GC42887 | Axitinib Sulfoxide | 1347304-18-0 | >98.00% | |
A major inactive metabolite of axitinib | ||||
| GC42913 | Benazeprilat | 86541-78-8 | >98.00% | |
An ACE inhibitor | ||||
| GC42915 | Benzamidine (hydrochloride) | 1670-14-0 | >99.00% | |
Benzamidine (hydrochloride)是一种可逆的、竞争性胰蛋白酶样丝氨酸蛋白酶抑制剂。 | ||||
| GC42978 | Bromamphenicol | 17371-30-1 | >99.00% | |
A dibrominated derivative of chloramphenicol | ||||
| GC43000 | Butyryl-L-carnitine (chloride) | 162067-50-7 | >95.00% | |
A butyrate ester of carnitine | ||||
| GC43030 | C16 dihydro Ceramide (d18:0/16:0) | 5966-29-0 | >98.00% | |
A bioactive sphingolipid | ||||
| GC43050 | C18 L-erythro Ceramide (d18:1/18:0) | 252039-52-4 | >98.00% | |
A naturally occurring ceramide | ||||
| GC43051 | C18 L-threo Ceramide (d18:1/18:0) | 95037-06-2 | >98.00% | |
A synthetic ceramide | ||||
| GC43052 | C18 Phytoceramide (t18:0/18:0) | 34354-88-6 | - | |
A bioactive sphingolipid | ||||
| GC43069 | C22 Ceramide (d18:1/22:0) | 27888-44-4 | >95.00% / >98.00% | |
C22 Ceramide (d18:1/22:0)是一种从海绵 Haliclona koremella 中分离的含有山萮酸的长链神经酰胺，是一种内源性生物活性鞘脂。 | ||||
| GC43114 | Caffeic Acid-13C3 | 1185245-82-2 | >95.00% | |
An internal standard for the quantification of caffeic acid | ||||
| GC43140 | Captopril Disulfide | 64806-05-9 | >95.00% | |
A metabolite and degradation product of captopril | ||||
| GC43141 | Carboxyatractyloside (potassium salt) | 35988-42-2 | >95.00% | |
An inhibitor of ADP/ATP translocases | ||||
| GC43144 | Carfilzomib Impurity 13 (hydrochloride) | 2319881-95-1 | >99.99% | |
A potential impurity found in commercial carfilzomib preparations | ||||
| GC43146 | Caspase-9 Inhibitor III (trifluoroacetate salt) | - | >95.00% | |
A caspase-9 inhibitor | ||||
| GC43153 | CAY10416 | 443919-96-8 | >95.00% | |
A dual COX-2/5-LO inhibitor | ||||
| GC43154 | CAY10443 | 582314-48-5 | >98.00% | |
A cytochrome c-dependent inducer of apoptosis | ||||
| GC43188 | CAY10680 | 1439488-21-7 | >98.00% | |
A dual inhibitor of monoamine oxidase B and adenosine A 2A receptors | ||||
| GC43192 | CAY10685 | 1613116-16-7 | >98.00% | |
A “clickable” analog of CPTH2 | ||||