Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC42693Acetaminophen Glucuronide (sodium salt)CAS: 120595-80-4纯度: >98.00%
An inactive metabolite of acetaminophen
- GC42694Acetaminophen sulfate (potassium salt)CAS: 32113-41-0纯度: >98.00%
An inactive metabolite of acetaminophen
- GC42697Acetyl Coenzyme A (sodium salt)CAS: 102029-73-2纯度: {{1}>90.00% / {2-4}>93.00% / {5-22}>98.00%}
乙酰辅酶A钠盐（Acetyl Coenzyme A (sodium salt)）是酶促乙酰基转移反应中必需的辅因子和酰基载体。Acetyl Coenzyme A 可作为组蛋白乙酰酶（HAT）的乙酰基供体，用于组蛋白和非组蛋白的翻译后乙酰化反应。
- GC42715Ac-VDVAD-CHO (trifluoroacetate salt)纯度: >95.00%
A caspase-2, caspase-3, and caspase-7 inhibitor
- GC42769all-trans Retinoyl β-D-GlucuronideCAS: 401-10-5纯度: >80.00%
A metabolite of all-trans retinoic acid
- GC42788Aminopeptidase N InhibitorCAS: 596108-59-7纯度: >95.00%
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).
- GC42818Antimycin A1CAS: 642-15-9纯度: >98.00%
An active component of the antimycin A antibiotic complex
- GC42820Antimycin A4CAS: 27220-59-3纯度: >98.00%
An active component of the antimycin A antibiotic complex
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC42637 | 9(S)-HpOTrE | 111004-08-1 | >98.00% | |
A 5-LO product derived from α-linolenic acid | ||||
| GC42651 | 9-oxo-10(E),12(E)-Octadecadienoic Acid | 54232-58-5 | >90.00% | |
A natural agonist of PPARα | ||||
| GC42653 | 9-OxoOTrE | 125559-74-2 | >95.00% | |
An antimicrobial oxidized fatty acid | ||||
| GC42665 | AAF-CMK (trifluoroacetate salt) | 184901-82-4 | >95.00% | |
An inhibitor of TPPII | ||||
| GC42667 | Abacavir Carboxylate | 384380-52-3 | >95.00% | |
An inactive metabolite of abacavir | ||||
| GC42688 | Ac-DMQD-CHO (trifluoroacetate salt) | - | >95.00% | |
An inhibitor of caspase-3 | ||||
| GC42690 | Acecainide (hydrochloride) | 34118-92-8 | >98.00% | |
An active metabolite of procainamide | ||||
| GC42693 | Acetaminophen Glucuronide (sodium salt) | 120595-80-4 | >98.00% | |
An inactive metabolite of acetaminophen | ||||
| GC42694 | Acetaminophen sulfate (potassium salt) | 32113-41-0 | >98.00% | |
An inactive metabolite of acetaminophen | ||||
| GC42695 | Acetoacetyl Coenzyme A (sodium salt hydrate) | - | >98.00% / >99.50% | |
A precursor to HMG-CoA | ||||
| GC42697 | Acetyl Coenzyme A (sodium salt) | 102029-73-2 | {{1}>90.00% / {2-4}>93.00% / {5-22}>98.00%} | |
乙酰辅酶A钠盐（Acetyl Coenzyme A (sodium salt)）是酶促乙酰基转移反应中必需的辅因子和酰基载体。Acetyl Coenzyme A 可作为组蛋白乙酰酶（HAT）的乙酰基供体，用于组蛋白和非组蛋白的翻译后乙酰化反应。 | ||||
| GC42709 | Ac-LEVD-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-4 inhibitor | ||||
| GC42715 | Ac-VDVAD-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-2, caspase-3, and caspase-7 inhibitor | ||||
| GC42718 | Ac-VEID-CHO (trifluoroacetate salt) | - | >95.00% | |
A caspase-6 inhibitor | ||||
| GC42742 | ADT-OH | 18274-81-2 | >97.00% | |
A synthetic H 2 S donor used in making chimeras | ||||
| GC42769 | all-trans Retinoyl β-D-Glucuronide | 401-10-5 | >80.00% | |
A metabolite of all-trans retinoic acid | ||||
| GC42777 | Amastatin (hydrochloride) | 100938-10-1 | >97.00% | |
An aminopeptidase inhibitor | ||||
| GC42788 | Aminopeptidase N Inhibitor | 596108-59-7 | >95.00% | |
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). | ||||
| GC42806 | Andrastin A | 174232-42-9 | >95.00% | |
A meroterpenoid farnesyltransferase inhibitor | ||||
| GC42818 | Antimycin A1 | 642-15-9 | >98.00% | |
An active component of the antimycin A antibiotic complex | ||||
| GC42820 | Antimycin A4 | 27220-59-3 | >98.00% | |
An active component of the antimycin A antibiotic complex | ||||
| GC42821 | AP219 | 779282-36-9 | >98.00% | |
A control compound for AP39 | ||||
| GC42823 | AP39 | 1429173-57-8 | >97.50% | |
A mitochondrial H 2 S donor | ||||
| GC42824 | APC 366 (trifluoroacetate salt) | - | >95.00% | |
A mast cell tryptase inhibitor | ||||