Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC424094-hydroxy Nebivolol (hydrochloride)CAS: 2717115-85-8纯度: >98.00%
A major metabolite of nebivolol
- GC424104-hydroxy NonenalCAS: 75899-68-2纯度: >98.00% / >97.00%
4-羟基壬烯醛（4-hydroxy Nonenal，4-HNE）是一种脂质过氧化（LPO）产物，是一种α，β不饱和羟基烯醛，由ω-6多不饱和脂肪酸氧化形成，它是一种无色油。
- GC424795(S)-HETrECAS: 195061-94-0纯度: >98.00%
A monohydroxy fatty acid synthesized by 5-LO from mead acid
- GC425515-hydroxymethyl Tolterodine (formate)CAS: 380636-49-7纯度: >98.00%
An active metabolite of tolterodine and fesoterodine
- GC425806-hydroxy ChlorzoxazoneCAS: 1750-45-4纯度: >97.00%
6-hydroxy Chlorzoxazone是Chlorzoxazone在体内的主要代谢产物。6-hydroxy Chlorzoxazone主要通过肝脏细胞色素P450酶系统形成，在生化研究中常作为探针用于定量评估CYP2E1的活性。
- GC426067-hydroxy Coumarin Glucuronide (sodium salt)CAS: 168286-98-4纯度: >95.00%
A 7-hydroxy coumarin phase II metabolite
- GC426077-hydroxy Coumarin sulfate (potassium salt)CAS: 1135316-80-1纯度: >98.00%
An internal standard for the quantification of 7-hydroxy coumarin
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC42405 | 4-hydroxy Atorvastatin (calcium salt) | 265989-44-4 | >90.00% | |
A metabolite of atorvastatin | ||||
| GC42407 | 4-hydroxy Diclofenac | 64118-84-9 | >97.00% | |
A CYP2C9 metabolite of the NSAID diclofenac | ||||
| GC42409 | 4-hydroxy Nebivolol (hydrochloride) | 2717115-85-8 | >98.00% | |
A major metabolite of nebivolol | ||||
| GC42410 | 4-hydroxy Nonenal | 75899-68-2 | >98.00% / >97.00% | |
4-羟基壬烯醛（4-hydroxy Nonenal，4-HNE）是一种脂质过氧化（LPO）产物，是一种α，β不饱和羟基烯醛，由ω-6多不饱和脂肪酸氧化形成，它是一种无色油。 | ||||
| GC42415 | 4-hydroxy Valsartan | 188259-69-0 | >98.00% | |
A major metabolite of valsartan | ||||
| GC42479 | 5(S)-HETrE | 195061-94-0 | >98.00% | |
A monohydroxy fatty acid synthesized by 5-LO from mead acid | ||||
| GC42484 | 5,6-dihydroxy Indole | 3131-52-0 | >95.00% / >99.00% | |
An intermediate in melanogenesis | ||||
| GC42546 | 5-hydroxy Diclofenac | 69002-84-2 | >98.00% | |
An active metabolite of diclofenac | ||||
| GC42548 | 5-hydroxy Saxagliptin (hydrochloride) | - | >95.00% | |
A major active metabolite of saxagliptin | ||||
| GC42549 | 5-hydroxy Thiabendazole | 948-71-0 | - | |
A major metabolite of thiabendazole | ||||
| GC42550 | 5-hydroxy-6-methoxy (S)-Duloxetine | 741693-79-8 | >95.00% | |
A metabolite of (S)-duloxetine | ||||
| GC42551 | 5-hydroxymethyl Tolterodine (formate) | 380636-49-7 | >98.00% | |
An active metabolite of tolterodine and fesoterodine | ||||
| GC42562 | 5-Methyl-2'-deoxycytidine | 838-07-3 | >98.00% | |
A pyrimidine nucleoside | ||||
| GC42578 | 6-Formylpterin | 712-30-1 | >98.00% | |
An intracellular generator of hydrogen peroxide | ||||
| GC42580 | 6-hydroxy Chlorzoxazone | 1750-45-4 | >97.00% | |
6-hydroxy Chlorzoxazone是Chlorzoxazone在体内的主要代谢产物。6-hydroxy Chlorzoxazone主要通过肝脏细胞色素P450酶系统形成，在生化研究中常作为探针用于定量评估CYP2E1的活性。 | ||||
| GC42584 | 6-O-desmethyl Donepezil | 120013-56-1 | >98.00% | |
An active metabolite of donepezil | ||||
| GC42586 | 6α-hydroxy Paclitaxel | 153212-75-0 | >95.00% | |
A metabolite of paclitaxel | ||||
| GC42606 | 7-hydroxy Coumarin Glucuronide (sodium salt) | 168286-98-4 | >95.00% | |
A 7-hydroxy coumarin phase II metabolite | ||||
| GC42607 | 7-hydroxy Coumarin sulfate (potassium salt) | 1135316-80-1 | >98.00% | |
An internal standard for the quantification of 7-hydroxy coumarin | ||||
| GC42608 | 7-hydroxy Methotrexate (sodium salt) | - | >96.00% | |
A metabolite of methotrexate | ||||
| GC42619 | 8(S)-HETrE | 889573-69-7 | >98.00% | |
A monohydroxy PUFA derivative of DGLA | ||||
| GC42626 | 8-hydroxy Efavirenz | 205754-33-2 | >98.00% | |
A major metabolite of efavirenz | ||||
| GC42633 | 9(E)-Erythromycin A oxime | 111321-02-9 | >95.00% | |
A metabolite of roxithromycin | ||||
| GC42636 | 9(S)-HOTrE | 89886-42-0 | >98.00% | |
A product of the action of 5-LO on α-linolenic acid | ||||