Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC419991-Methylhistamine (hydrochloride)CAS: 6481-48-7纯度: >99.50% / >97.00%
1-Methylhistamine (hydrochloride)是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平。
- GC42000TRIA-662 (1-Methylnicotinamide chloride)CAS: 1005-24-9纯度: >98.00%
TRIA-662 (1-Methylnicotinamide chloride)是烟酰胺经烟酰胺N-甲基转移酶（NNMT）催化生成的主要代谢产物。
- GC421502'-Deoxycytidine 5'-diphosphate (sodium salt hydrate)CAS: 151151-32-5纯度: >98.00%
A nucleotide diphosphate
- GC421983-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt)CAS: 1346603-21-1纯度: >98.00%
An inactive metabolite of baclofen
- GC423704-desmethoxy OmeprazoleCAS: 110374-16-8纯度: >98.00%
A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations
- GC424014-hydroperoxy CyclophosphamideCAS: 39800-16-3纯度: >98.00% / >95.00%
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
- GC424024-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)纯度: >95.00%
An inactive metabolite of (S)-duloxetine
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC41940 | 15-OxoEDE | 105835-44-7 | >95.00% | |
A PUFA produced by oxidation of 15-HEDE | ||||
| GC41951 | 17(R)-Resolvin D1 | 528583-91-7 | >95.00% | |
An aspirin-triggered epimer of RvD1 | ||||
| GC41952 | 17(R)-Resolvin D4 | 528583-89-3 | >98.00% | |
An aspirin-triggered epimer of RvD4 | ||||
| GC41955 | 17-DMAG | 467214-20-6 | >98.00% | |
Water-soluble inhibitor of Hsp90 | ||||
| GC41980 | 18-carboxy dinor Leukotriene B4 | 102674-12-4 | >97.00% | |
β-oxidation metabolite of LTB 4 | ||||
| GC41999 | 1-Methylhistamine (hydrochloride) | 6481-48-7 | >99.50% / >97.00% | |
1-Methylhistamine (hydrochloride)是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平。 | ||||
| GC42000 | TRIA-662 (1-Methylnicotinamide chloride) | 1005-24-9 | >98.00% | |
TRIA-662 (1-Methylnicotinamide chloride)是烟酰胺经烟酰胺N-甲基转移酶（NNMT）催化生成的主要代谢产物。 | ||||
| GC42039 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC | 154436-51-8 | >98.00% | |
An oxidized phospholipid | ||||
| GC42040 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE | 947381-58-0 | >98.00% | |
An oxidized phospholipid | ||||
| GC42041 | 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC | 154436-48-3 | >98.00% | |
An oxidized phospholipid | ||||
| GC42042 | 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE | 154436-49-4 | >90.00% | |
An oxidized phospholipid | ||||
| GC42082 | 20-carboxy Leukotriene B4 | 80434-82-8 | >97.00% | |
A LTB 4 metabolite | ||||
| GC42150 | 2'-Deoxycytidine 5'-diphosphate (sodium salt hydrate) | 151151-32-5 | >98.00% | |
A nucleotide diphosphate | ||||
| GC42189 | 2-oxo Clopidogrel | 109904-27-0 | >98.00% | |
An intermediary metabolite of clopidogrel | ||||
| GC42193 | 2-Thenoyltrifluoroacetone | 326-91-0 | >99.00% | |
An inhibitor of respiration | ||||
| GC42198 | 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt) | 1346603-21-1 | >98.00% | |
An inactive metabolite of baclofen | ||||
| GC42201 | 3,3'-Diiodo-L-thyronine | 4604-41-5 | >98.00% | |
A metabolite of thyroid hormone | ||||
| GC42274 | 3-hydroxy Darifenacin | 206048-82-0 | >95.00% | |
A metabolite of darifenacin | ||||
| GC42275 | 3-hydroxy Desloratidine | 119410-08-1 | >98.00% | |
A major metabolite of desloratadine | ||||
| GC42307 | 3-O-methyl-L-DOPA (hydrate) | 200630-46-2 | >98.00% | |
A metabolite of L-DOPA | ||||
| GC42351 | 4-carboxy TEMPO | 37149-18-1 | >97.00% | |
A spin label | ||||
| GC42370 | 4-desmethoxy Omeprazole | 110374-16-8 | >98.00% | |
A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations | ||||
| GC42401 | 4-hydroperoxy Cyclophosphamide | 39800-16-3 | >98.00% / >95.00% | |
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。 | ||||
| GC42402 | 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt) | - | >95.00% | |
An inactive metabolite of (S)-duloxetine | ||||