D-Glucose-6-phosphate (sodium salt) is an essential component of glucose metabolism. It is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or glucose-1-phosphate is converted by phosphoglucomutase, which is the first step in glycogen synthesis [1]. D-Glucose 6-Phosphate is located at the starting point of two major metabolic pathways: glycolysis and the pentose phosphate pathway [2]. D-Glucose 6-Phosphate can be converted to glycogen or starch and stored in cells [3]. D-Glucose 6-Phosphate can be used as a substrate to measure the activity of recombinant mannitol-1-phosphatase (M1Pase) [4]. D-Glucose 6-Phosphate can be used as a substrate to measure the specificity of SapM protein [5]. This product is the sodium salt form of D-Glucose 6-Phosphate, with a molecular formula of C6H12NaO9P and a molecular weight of 282.12.
References:
[1]Jang W, Gomer R H. Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum[J]. Eukaryotic cell, 2005, 4(1): 72-81.
[2]Litwack, Gerald .Chapter 6-Insulin and Sugars.Human Biochemistry. Academic Press.2018:131–160.
[3]Lal M A. Metabolism of storage carbohydrates[J]. Plant physiology, development and metabolism. Springer Nature, Singapore. Doi, 2018, 10: 978-981.
[4] Groisillier A, Tonon T. Determination of Recombinant Mannitol-1-phosphatase Activity from Ectocarpus sp[J]. Bio-protocol, 2016, 6(16): e1896-e1896.
[5]Fernandez-Soto P, Bruce A J E, Fielding A J, et al. Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs[J]. Scientific reports, 2019, 9(1): 10315.
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步[1]。D-Glucose 6-Phosphate位于两个主要代谢途径的起点：糖酵解和磷酸戊糖途径[2]。D-Glucose 6-Phosphate可以转化为糖原或淀粉储存在细胞中[3]。D-Glucose 6-Phosphate可作为底物用于测定重组甘露醇-1-磷酸酶（M1Pase）活性[4]。D-Glucose 6-Phosphate可作为底物用于测定SapM蛋白的特异性[5]。本产品是D-Glucose 6-Phosphate的钠盐形式，分子式为C6H12NaO9P，分子量为282.12。