GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC61436 structure
    GC61436Gallic acid hydrate
    CAS: 5995-86-8
    纯度: >98.00%

    A phenol with diverse biological activities

  • GC61442 structure
    GC614421-Methylguanidine hydrochloride
    CAS: 21770-81-0
    纯度: >98.00%

    Methylguanidine is a guanidine compound deriving from protein catabolism.

  • GC61443 structure
    GC61443Thiamine monophosphate chloride (dihydrate)
    CAS: 273724-21-3
    纯度: >98.00% / >99.00%

    Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) is an endogenous metabolite.

  • GC61448 structure
    GC61448ATP disodium trihydrate
    CAS: 51963-61-2
    纯度: >98.00%

    ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.

  • GC61460 structure
    GC61460Dihydroxyacetone phosphate hemimagnesium hydrate
    纯度: >95.00%

    Dihydroxyacetonephosphate在脂质生物合成和糖酵解中是重要的中间产物。它是一种参与多种代谢途径的生化化合物，包括植物的卡尔文循环和糖酵解。Dihydroxyacetonephosphate被发现与醛缩酶缺乏有关，这是一种先天性代谢错误。

  • GC61463 structure
    GC61463p-Ethynylphenylalanine
    CAS: 278605-15-5
    纯度: >97.00%

    p-Ethynylphenylalanine(4-Ethynyl-L-phenylalanine)是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶(TPH)抑制剂，其Ki值为32.6μM。

  • GC61478 structure
    GC61478N-Desmethyl Pimavanserin
    CAS: 639863-77-7

    N-DesmethylPimavanserin是Pimavanserin的活性代谢物。Pimavanserin是选择性的5-HT2A受体反向激动剂，pIC50和pKd分别为8.73和9.3。

  • GC61482 structure
    GC61482sn-Glycerol 3-phosphate lithium
    纯度: >98.00% / >95.00% / >99.00%

    sn-Glycerol3-phosphatelithium是由胞质甘油3-磷酸脱氢酶途径产生的，利用糖酵解过程中形成的NADH减少二羟丙酮磷酸。

  • GC61487 structure
    GC61487all-trans-Anhydro Retinol
    CAS: 1224-78-8
    纯度: >90.00%

    all-trans-AnhydroRetinol(AnhydrovitaminA)是维生素A的代谢产物。all-trans-AnhydroRetinol用于合成的多种维生素制剂。

  • GC61494 structure
    GC61494D-Sedoheptulose 7-phosphate
    CAS: 2646-35-7
    纯度: >95.00%

    An intermediate in the pentose phosphate pathway

  • GC61495 structure
    GC61495Thrombin (MW 37kDa)
    CAS: 9002-04-4
    纯度: 不显示 / SA-2110 U/mg protein / SA-2000 U/mg protein

    凝血酶 (MW 37kDa) 是一种 Na+- 激活的变构丝氨酸蛋白酶。

  • GC61496 structure
    GC61496Angiotensin (1-7) (acetate)
    CAS: 2855063-75-9
    纯度: >98.50%

    Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.

  • GC61511 structure
    GC61511Angstrom6
    CAS: 220334-14-5
    纯度: >99.00%

    Angstrom6(A6Peptide)是一种来源于单链尿激酶纤溶酶原激活剂(scuPA)的8个氨基酸的肽，可干扰uPA/uPAR级联反应并消除下游效应。Angstrom6与CD44结合，抑制肿瘤细胞的迁移、侵袭和转移，调节CD44介导的细胞信号。

  • GC61536 structure
    GC61536Beclomethasone 17-propionate
    CAS: 5534-18-9
    纯度: >95.00%

    Beclomethasone17-propionate(Beclomethasone-17-monopropionate)是Beclomethasonedipropionate的活性代谢产物，是糖皮质激素受体(GR)激动剂。Beclomethasone17-propionate对GR的亲和力比Beclomethasonedipropionate高。Beclomethasone17-propionate有效抑制慢性阻塞性肺疾病(COPD)肺巨噬细胞中细胞因子的产生。

  • GC61538 structure
    GC6153811-Oxo etiocholanolone
    CAS: 739-27-5
    纯度: >96.00%

    11-oxo Etiocholanolone 是皮质醇和 11-酮睾酮的代谢产物。由皮质醇经可的松和四氢可的酮中间体形成，由11-酮睾酮经5β-11-酮二氢睾酮和3α-11-酮基胆二醇中间体形成.?妊娠期间 11-氧代胆烷醇酮的尿液水平升高，并且在子宫平滑肌瘤患者中升高。11-氧代胆烷醇酮的粪便水平已被用作家畜和散养反刍动物压力的标志物。

  • GC61563 structure
    GC61563Aminohexylgeldanamycin
    CAS: 485395-71-9

    Aminohexylgeldanamycin(AHGDM)，Geldanamycin的衍生物，是一种热休克蛋白90(HSP90)抑制剂。Aminohexylgeldanamycin具有抗血管生成和抗肿瘤活性。

  • GC61576 structure
    GC61576Robinetin
    CAS: 490-31-3
    纯度: >97.00%

    A flavonol with diverse biological activities

  • GC61582 structure
    GC615823-Phenyltoxoflavin
    CAS: 32502-63-9
    纯度: >99.50%

    3-Phenyltoxoflavin是Toxoflavin的衍生物，是一种Hsp90抑制剂，抑制Hsp90-TPR2A之间相互作用的Kd值为585nM。3-Phenyltoxoflavin具有抗癌活性。

  • GC61599 structure
    GC61599GW604714X
    CAS: 853953-65-8
    纯度: >98.00%

    GW604714X是丙酮酸支持的线粒体呼吸(mitochondrialrespiration)的有效选择性抑制剂。GW604714X抑制线粒体丙酮酸载体(MPC)的Ki值<0.1μM。GW604714X也能抑制质膜单羧酸转运蛋白MCT1对L-乳酸的转运，但其浓度要比MPC高4个数量级。

  • GC61604 structure
    GC61604Guanylin(human) TFA
    纯度: >97.00%

    Guanylin(human)TFA，一种15个氨基酸的肽，是一种内源性肠鸟苷酸环化酶(intestinalguanylatecyclase)激活剂。Guanylin(human)TFA主要存在于胃肠道中，其通过cGMP依赖性机制调节肠和肾上皮中电解质水的运输。

  • GC61614 structure
    GC61614Succinyladenosine
    CAS: 4542-23-8
    纯度: >99.00%

    Succinyladenosine，是胞内腺苷酸(S-AMP)经5-核苷酸酶脱磷酸化的产物，是腺苷酸琥珀酸酶(ASL)缺乏的生化标志。

  • GC61631 structure
    GC61631Pactimibe
    CAS: 189198-30-9
    纯度: >98.00%

    Pactimibe(CS-505freebase)是一种ACAT1/2双重抑制剂，对于ACAT1的IC50值为4.9μM，对于ACAT2的IC50值为3.0μM。Pactimibe(CS-505freebase)抑制ACAT，其IC50值在肝细胞中是2.0μM，在巨噬细胞中是2.7μM，在THP-1细胞中是4.7μM。Pactimibe(CS-505freebase)非竞争性抑制oleoyl-CoA，Ki是5.6μM。此外，Pactimibe(CS-505freebase)明显抑制胆固醇酯的形成，IC50是6.7μM。Pactimibe(CS-505freebase)具有抗动脉粥样硬化的潜力，可降低血浆胆固醇的活性。

  • GC61634 structure
    GC61634Mitochondrial respiration-IN-1 hydrobromide
    纯度: >99.50%

    Mitochondrialrespiration-IN-1hydrobromide(compound49)是一种有效的线粒体(mitochondrial)抑制剂(IC50=8.8mg/mL)，可显著降低血小板的线粒体呼吸。

  • GC61647 structure
    GC61647(+)-Longifolene
    CAS: 475-20-7
    纯度: >90.00%

    (+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins