11-oxo Etiocholanolone is a metabolite of cortisol and 11-keto testosterone.1,2 It is formed from cortisol via cortisone and tetrahydrocortistone intermediates, and it is formed from 11-keto testosterone via 5β-11-keto dihydrotestosterone and 3α-11-keto etiocholanediol intermediates. Urinary levels of 11-oxo etiocholanolone increase during pregnancy and are elevated in patients with uterine leiomyomas.3,4 Fecal levels of 11-oxo etiocholanolone have been used as a marker of stress in domestic livestock and free-range ruminants.5
1.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 2.Barnard, L., Nikolaou, N., Louw, C., et al.The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1J. Steroid Biochem. Mol. Biol.202105724(2020) 3.Birke, G., Gemzell, C.A., Plantin, L.O., et al.Plasma levels of 17-hydroxycorticosteroids and urinary excretion pattern of keto-steroids in normal pregnancyActa Endocrinol. (Copenh.)27(4)389-402(1958) 4.Jung, B.H., Bai, S.W., and Chung, B.C.Endogenous urinary steroids in premenopausal women with uterine leiomyomasInt. J. Gynaecol. Obstet.84(1)55-60(2004) 5.Molina-García, L., Pérez, J.M., Sarasa, M., et al.HPLC-QTOF method for quantifying 11-ketoetiocholanolone, a cortisol metabolite, in ruminants' feces: Optimization and validationEcol. Evol.8(18)9218-9228(2018)