7-Demethylsuberosin is a prenylated coumarin that has been found in Angelica tenuissima and has anti-inflammatory and neuroprotective activities.1,2 It inhibits histamine release induced by phorbol 12-myristate 13-acetate and A23187 from HMC-1 human mast cell leukemia cells when used at a concentration of 10 ?M.1 7-Demethylsuberosin (0.1-10 ?M) protects against glutamate-induced cytotoxicity in primary rat cortical cells.2
1.Choi, H.G., Je, I.-G., Kim, G.J., et al.Chemical constituents of the root of Angelica tenuissima and their anti-allergic inflammatory activityNat. Prod. Commun.12(5)779-780(2017) 2.Kang, S.Y., and Kim, Y.C.Neuroprotective coumarins from the root of Angelica gigas: Structure-activity relationshipsArch. Pharm. Res.30(11)1368-1373(2007)