GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC61130 structure
    GC61130NHC-triphosphate
    CAS: 34973-27-8
    纯度: >99.00%

    NHC-triphosphate是NHC的活性胞内磷酸盐代谢物(intracellularmetabolite)，以三磷酸盐的形式存在。NHC-triphosphate是病毒聚合酶(viralpolymerase)的弱底物替代物，会被并入HCV复制子RNA中。

  • GC61137 structure
    GC61137Nordoxepin D3 hydrochloride
    CAS: 1331665-54-3
    纯度: >99.00%

    NordoxepinD3hydrochloride(DesmethyldoxepinD3hydrochloride)是Nordoxepinhydrochloride的氘代物。Nordoxepinhydrochloride是Doxepinhydrochloride的活性代谢产物，Doxepinhydrochloride具有口服活性和抗抑郁作用。

  • GC61144 structure
    GC61144Octadecanal
    CAS: 638-66-4
    纯度: >98.00%

    Octadecanal是一种长链醛，存在于大腿和胸部肌肉中。

  • GC61145 structure
    GC61145Octadecanedioic acid
    CAS: 871-70-5

    Octadecanedioicacid是一种内源性代谢物，一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。

  • GC61147 structure
    GC61147O-desmethyl Mebeverine acid
    CAS: 586357-02-0
    纯度: >98.00%

    A metabolite of mebeverine

  • GC61150 structure
    GC61150O-Desmethylangolensin
    CAS: 21255-69-6
    纯度: >98.50%

    A phytoestrogen and an active metabolite of diadzein

  • GC61158 structure
    GC61158ONO-5334
    CAS: 868273-90-9
    纯度: >99.50%

    ONO-5334是一种强效、选择性和口服活性的组织蛋白酶K(cathepsinK)抑制剂，对人、兔和大鼠组织蛋白酶K的作用值分别为0.10nM、0.049nM和0.85nM。ONO-5334是一种有效的抗SAR-COV-2病毒活性的抗病毒化合物，其EC50值为500nM。ONO-5334有潜力用于骨质疏松症以及COVID-19的相关研究。

  • GC61164 structure
    GC61164Oxytetracycline hydrochloride
    CAS: 2058-46-0
    纯度: >98.00%

    A broad-spectrum antibiotic

  • GC61165 structure
    GC61165Paeoniflorgenin
    CAS: 697300-41-7
    纯度: >90.00%

    Paeoniflorgenin是Paeoniflorin的去糖基化代谢产物。

  • GC61180 structure
    GC61180Phenidone
    CAS: 92-43-3
    纯度: >98.00%

    Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.

  • GC61181 structure
    GC61181Phenylpropiolic acid
    CAS: 637-44-5

    Phenylpropiolicacid是一种内源性代谢产物。

  • GC61182 structure
    GC61182Phosphoramide mustard (cyclohexanamine)
    CAS: 1566-15-0
    纯度: >95.00%

    An alkylating agent and active metabolite of cyclophosphamide

  • GC61274 structure
    GC61274Senecionine acetate
    CAS: 126642-77-1

    Senecionineacetate(O-Acetylsenecionine)是吡咯烷核生物碱。Senecionineacetate通过使游离巯基失活来抑制线粒体和线粒体区室中Ca2+的螯合。

  • GC61298 structure
    GC61298Sulcatone
    CAS: 110-93-0
    纯度: >98.00%

    Sulcatone是一种内源性代谢产物。

  • GC61310 structure
    GC61310SY-640
    CAS: 168705-70-2
    纯度: >98.00%

    SY-640是乙酰胺衍生物，具有有效的保肝作用。SY-640可减轻痤疮丙酸杆菌和脂多糖诱导的小鼠肝损伤。

  • GC61318 structure
    GC61318Tectol
    CAS: 24449-39-6

    Tectol，从Lippiasidoides中分离，对人白血病细胞株HL60和CEM具有显著的抑制作用。Tectol是一种farnesyltransferase(FTase)抑制剂，在人和布氏锥虫的IC50分别为2.09和1.73μM。Tectol抑制耐药恶性疟原虫(FcB1)，IC50为3.44μM。

  • GC61323 structure
    GC61323Tetrac
    CAS: 67-30-1
    纯度: >98.00%

    Tetrac(Tetraiodothyroaceticacid)，L-甲状腺素(T4)的天然衍生物，是甲状腺素整合素受体拮抗剂。Tetrac阻断T4和3,5,3'-triiodo-L-thyronine(T3)在整联蛋白αvβ3上甲状腺激素的细胞表面受体处的作用。Tetra具有抗血管生成和抗肿瘤活性。

  • GC61325 structure
    GC61325Tetradecanedioic acid
    CAS: 821-38-5

    Tetradecanedioic acid (Tetradecanedicarboxylate) is a C14 dicarboxylic acid.

  • GC61343 structure
    GC61343trans-2-Hexadecenoyl-L-carnitine
    CAS: 26145-55-1

    trans-2-Hexadecenoyl-L-carnitine是一种内源性代谢产物，存在于尿液中。

  • GC61350 structure
    GC61350Tridecanedioic acid
    CAS: 505-52-2
    纯度: >95.00%

    1,11-Undecanedicarboxylic acid (Tridecanedioic acid, Brassylic acid, Brassilic acid) is an unusual odd-numbered dicarboxylic acid that appears in the urines of children with neonatal adrenoleukodystrophy and Zellweger syndrome, as an additional marker of these peroxisomal disorders.

  • GC61353 structure
    GC61353Trimethoprim N-oxide
    CAS: 27653-68-5

    TrimethoprimN-oxide(Trimethoprim1-N-oxide)属于人尿代谢物。TrimethoprimN-oxide是通过氧化嘧啶环中的氮原子生成的。TrimethoprimN-oxide主要由CYP1A2在人肝微粒体中形成。

  • GC61354 structure
    GC61354Trimethylamine N-oxide dihydrate
    CAS: 62637-93-8
    纯度: >98.00%

    A metabolite of choline, phosphatidylcholine, and L-carnitine

  • GC61424 structure
    GC61424Phenylglyoxylic acid
    CAS: 611-73-4
    纯度: >98.50%

    Phenylglyoxylic acid (Benzoyl formate, Phenylglyoxalic acid, Phenylglyoxylate) is a key building block in the field of chemical synthesis and is widely used to synthesize pharmaceutical intermediates or food additives.

  • GC61431 structure
    GC61431DL-Asparagine
    CAS: 3130-87-8
    纯度: >98.00%

    DL-Asparagine是L-Aparagine和D-Aparagine对映异构体的外消旋混合物。DL-Asparagine可以用于细菌的生长培养基中。