GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC60976 structure
    GC60976L-Aspartic aicd sodium
    CAS: 3792-50-5
    纯度: >97.00%

    L-Asparticaicdsodium是一种氨基酸，被证明是一种结肠特异性药物输送的前体药物。

  • GC60978 structure
    GC60978L-Chicoric Acid
    CAS: 70831-56-0
    纯度: >99.50%

    A dicaffeoyl ester with diverse biological activities

  • GC60979 structure
    GC60979L-Cysteine hydrochloride hydrate
    CAS: 7048-04-6
    纯度: >98.00%

    L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification.

  • GC60991 structure
    GC60991L-Homocysteine
    CAS: 6027-13-0
    纯度: >98.50%

    L-Homocysteine是一种含硫氨基酸，作为必需氨基酸蛋氨酸（Met）的中间代谢产物存在。

  • GC60999 structure
    GC60999L-Norvaline
    CAS: 6600-40-4
    纯度: >98.00%

    An inhibitor of arginase and p70S6K1

  • GC61007 structure
    GC61007L-Sepiapterin
    CAS: 17094-01-8
    纯度: >98.00%

    L-Sepiapterin(Sepiapterin)是内皮型一氧化氮合酶(eNOS)辅因子四氢生物喋呤(BH4)的前体。L-Sepiapterin改善db/db小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin通过下调p70S6K依赖性VEGFR-2表达抑制卵巢癌细胞增殖和迁移。

  • GC61013 structure
    GC61013Lumisterol 3 (>90%)
    CAS: 5226-01-7
    纯度: >98.00%

    A photoisomer of previtamin D 3

  • GC61027 structure
    GC61027m-Anisaldehyde
    CAS: 591-31-1
    纯度: >99.50%

    m-Anisaldehyde是一种内源性代谢产物。

  • GC61037 structure
    GC61037Mebeverine acid
    CAS: 475203-77-1

    A metabolite of mebeverine

  • GC61041 structure
    GC61041Mepazine hydrochloride
    CAS: 2975-36-2
    纯度: >98.00%

    Mepazinehydrochloride(Pecazinehydrochloride)是一种有效的选择性MALT1蛋白酶抑制剂。Mepazinehydrochloride抑制全长GSTMALT1和GSTMALT1325-760段的IC50分别为0.83和0.42μM。Mepazinehydrochloride通过增强细胞凋亡(apoptosis)来影响ABC-DLBCL细胞的生存能力。

  • GC61044 structure
    GC61044Mesitaldehyde
    CAS: 487-68-3
    纯度: >95.00%

    Mesitaldehyde是一种内源性代谢产物。

  • GC61048 structure
    GC61048Methoxyacetic acid
    CAS: 625-45-6
    纯度: >98.00%

    Methoxyaceticacid是一种内源性代谢产物。

  • GC61049 structure
    GC61049Methyl 3-phenylpropanoate
    CAS: 103-25-3
    纯度: >99.50%

    Methyl3-phenylpropanoate是一种内源性代谢产物。

  • GC61050 structure
    GC61050Methyl acetylacetate
    CAS: 105-45-3
    纯度: >98.00%

    Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.

  • GC61051 structure
    GC61051Methyl anisate
    CAS: 121-98-2

    Methylanisate是一种内源性代谢产物。

  • GC61053 structure
    GC61053Methyl cyclohexanecarboxylate
    CAS: 4630-82-4

    An aliphatic ester

  • GC61056 structure
    GC61056Methyl phenylacetate
    CAS: 101-41-7
    纯度: >98.00%

    Methylphenylacetate是一种内源性代谢产物。

  • GC61057 structure
    GC61057Methyl p-tert-butylphenylacetate
    CAS: 3549-23-3

    Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour.

  • GC61081 structure
    GC61081Monobenzyl phthalate
    CAS: 2528-16-7
    纯度: >98.00%

    Monobenzylphthalate(2-((Benzyloxy)carbonyl)benzoicacid)是暴露于邻苯二甲酸盐(如，邻苯二甲酸二乙基己酯)后的尿代谢物(urinarymetabolite)。

  • GC61083 structure
    GC61083Monomethyl phthalate
    CAS: 4376-18-5
    纯度: >95.00%

    Monomethylphthalate是一种邻苯二甲酸代谢物(metabolite)。Monomethylphthalate作为暴露于phthalate后的尿液生物标记物，可作为甲状腺癌和良性结节的检测指标。

  • GC61103 structure
    GC61103N,N,O-Tridesmethylvenlafaxine
    CAS: 149289-29-2

    N,N,O-Tridesmethylvenlafaxine是一种内源性代谢产物。

  • GC61105 structure
    GC61105N4-Acetylcytidine
    CAS: 3768-18-1
    纯度: >99.50%

    A catabolite of cytidine

  • GC61107 structure
    GC61107N-Acetyl-L-glutamic acid
    CAS: 1188-37-0
    纯度: >98.00%

    N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.

  • GC61115 structure
    GC61115N-Desethyl Oxybutynin D5 hydrochloride
    CAS: 1173018-49-9

    N-DesethylOxybutyninD5hydrochloride是N-DesethylOxybutyninhydrochloride的氘代物。N-DesethylOxybutynin是Oxybutynin的活性代谢产物。Oxybutynin是一种抗胆碱能药，抑制电压依赖型K+通道。