GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC60768 structure
    GC60768Dibenzyl disulfide
    CAS: 150-60-7

    Dibenzyldisulfide是一种内源性代谢产物。

  • GC60779 structure
    GC60779Dimethylmalonic acid
    CAS: 595-46-0
    纯度: >98.00%

    Dimethylmalonicacid是人血清中的短链二羧酸。Dimethylmalonicacid也是在肺泡呼吸中检测到的挥发性有机化合物。

  • GC60780 structure
    GC60780Diphenyl disulfide
    CAS: 882-33-7
    纯度: >98.50%

    Diphenyldisulfide是一种内源性代谢产物。

  • GC60784 structure
    GC60784DL-Tryptophan
    CAS: 54-12-6
    纯度: >99.50%

    A racemic mixture of D- and L-tryptophan

  • GC60793 structure
    GC60793D-Ribonolactone
    CAS: 5336-08-3
    纯度: >95.00%

    D-Ribonolactone是一种糖内酯，也是一种大肠杆菌β-半乳糖苷酶(β-galactosidase)的抑制剂，Ki为26mM。

  • GC60819 structure
    GC60819Ethoxyacetic acid
    CAS: 627-03-2
    纯度: >97.00%

    Ethoxyaceticacid是一种内源性代谢产物。

  • GC60828 structure
    GC60828Evogliptin tartrate
    CAS: 1222102-51-3
    纯度: >99.50%

    Evogliptintartrate是一种高效、口服有效、选择性的DPP-4抑制剂，具有抗糖尿病活性。Evogliptintartrate可用于靶向动脉炎症和动脉粥样硬化的研究。

  • GC60831 structure
    GC60831Ezetimibe phenoxy glucuronide
    CAS: 190448-57-8
    纯度: >99.00%

    Ezetimibephenoxyglucuronide(Ezetimibeglucuronide)是Ezetimibe的活性代谢物，具有抗高脂蛋白血症效果。Ezetimibe是有效的胆固醇吸收抑制剂。

  • GC60833 structure
    GC60833FB23
    CAS: 2243736-35-6
    纯度: >99.00%

    FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.

  • GC60856 structure
    GC60856FOY 251
    CAS: 71079-09-9
    纯度: >98.50%

    An active metabolite of camostat

  • GC60858 structure
    GC60858Freselestat quarterhydrate
    纯度: >99.00%

    Freselestatquarterhydrate(ONO-6818quarterhydrate)是一种有效且具有口服活性的嗜中性粒细胞弹性蛋白酶(neutrophilelastase)抑制剂，Ki为12.2nM。Freselestatquarterhydrate对其他蛋白酶（例如胰蛋白酶，蛋白酶3，胰弹性蛋白酶，纤溶酶，凝血酶，胶原酶，组织蛋白酶G和鼠巨噬细胞弹性蛋白酶）的活性低100倍以上，并具有有效的抗炎活性。

  • GC60859 structure
    GC60859Fructosyl-lysine dihydrochloride
    CAS: 96192-35-7
    纯度: >95.00%

    Fructosyl-lysine(Fructoselysine)dihydrochloride是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物(amadoriglycation)。Fructosyl-lysine是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。

  • GC60860 structure
    GC60860FSL-1 TFA
    纯度: >98.00%

    FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.

  • GC60861 structure
    GC60861FTI-2153
    CAS: 344900-92-1
    纯度: >99.00%

    FTI-2153是一种有效、高度选择性的法尼基转移酶farnesyltransferase(FTase)抑制剂，IC50为1.4nM。FTI-2153有效抑制H-Ras蛋白的加工修饰，IC50值为10nM，是对其抑制活性是对Rap1A蛋白加工的3000多倍。

  • GC60871 structure
    GC60871Gemigliptin tartrate
    CAS: 1374639-74-3
    纯度: >98.00%

    A DPP-4 inhibitor

  • GC60898 structure
    GC60898H-His-OH.HCl.H2O
    CAS: 5934-29-2
    纯度: >97.00%

    L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.

  • GC60916 structure
    GC60916Hydroxyacetone
    CAS: 116-09-6
    纯度: >97.00%

    Hydroxyacetone是一种内源性代谢产物。

  • GC60920 structure
    GC60920Hydroxyhexamide
    CAS: 3168-01-2
    纯度: >99.50%

    Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.

  • GC60933 structure
    GC60933Imidazol-1-yl-acetic acid
    CAS: 22884-10-2

    Imidazol-1-yl-aceticacid是一种内源性代谢产物。

  • GC60934 structure
    GC60934Indole-3-methanamine
    CAS: 22259-53-6
    纯度: >95.00%

    Indole-3-methanamine是大麦、谷类食物的摄取生物标志物。

  • GC60942 structure
    GC60942Isobutyryl-L-carnitine chloride
    CAS: 6920-31-6
    纯度: >98.00%

    An acylcarnitine

  • GC60947 structure
    GC60947Isoeuphorbetin
    CAS: 50886-61-8

    Isoeuphorbetin，一种从Violaphilippica中分离的二聚香豆素，是一种强效HCV蛋白酶(HCVprotease)抑制剂，IC50为3.63µg/mL。

  • GC60948 structure
    GC60948Isohomovanillic acid
    CAS: 1131-94-8

    Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.

  • GC60960 structure
    GC60960JPM-OEt
    CAS: 262381-84-0
    纯度: >98.50%

    JPM-OEt是一种广谱的半胱氨酸组织蛋白酶(cysteinecathepsin)抑制剂。JPM-OEt在活性位点共价结合，并且不可逆地抑制半胱氨酸组织蛋白酶家族。具有抗肿瘤活性。