GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC60515 structure
    GC605154-Ethylbenzaldehyde
    CAS: 4748-78-1
    纯度: >99.00%

    4-Ethylbenzaldehyde是一种内源性代谢产物。

  • GC60516 structure
    GC605164-Ethynyl-L-phenylalanine hydrochloride
    CAS: 188640-63-3
    纯度: >99.00% / >98.00%

    4-Ethynyl-L-phenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种有效的、选择性的、可逆的和竞争性的色氨酸羟化酶 (TPH) 抑制剂，Ki 为 32.6 μM.

  • GC60517 structure
    GC605174-Hydroxyatomoxetine
    CAS: 435293-66-6

    A metabolite of atomoxetine

  • GC60518 structure
    GC605184-Hydroxybenzyl cyanide
    CAS: 14191-95-8

    4-Hydroxybenzylcyanide是一种内源性代谢产物。

  • GC60521 structure
    GC605214-Methyl-1-phenyl-2-pentanone
    CAS: 5349-62-2
    纯度: >99.50%

    4-Methyl-1-phenyl-2-pentanone是一种内源性代谢产物。

  • GC60523 structure
    GC605234-Methylamino antipyrine hydrochloride
    CAS: 856307-27-2

    An active metabolite of metamizole

  • GC60524 structure
    GC605244-Pentenoic acid
    CAS: 591-80-0
    纯度: >99.50%

    4-Pentenoic acid (Allylacetic acid, 3-vinylpropionic acid, 4-penten-1-oic acid), a flavouring ingredient, is used to inhibit fatty acid oxidation in rat heart mitochondria.

  • GC60525 structure
    GC605254-Vinylphenol (10%w/w in propylene glycol)
    CAS: 2628-17-3
    纯度: 不显示

    4-Vinylphenol存在于药用草白花蛇舌草，野生稻中，也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol诱导凋亡(apoptosis)，在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。

  • GC60529 structure
    GC605295-Hydroxy-2'-deoxyuridine
    CAS: 5168-36-5
    纯度: >98.00%

    5-Hydroxy-2'-deoxyuridine(5-OHdU)是一种2'-Deoxycytidine的主要稳定氧化产物。5-Hydroxy-2'-deoxyuridine可以通过DNA聚合酶在体外掺入DNA。

  • GC60531 structure
    GC605315α-Cholestan-3-one
    CAS: 566-88-1
    纯度: >98.00%

    5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase.

  • GC60541 structure
    GC605418-Demethyl Ivabradine
    CAS: 304464-97-9

    8-DemethylIvabradine是Ivabradine的一个代谢物。Ivabradine是具有口服活性的，超极化激活的环核苷酸门控离子通道(HCN)通道阻滞剂。

  • GC60548 structure
    GC60548ABT-100
    CAS: 450839-40-4
    纯度: >98.00%

    ABT-100是一种有效的，高选择性和口服活性的farnesyltransferase抑制剂。ABT-100抑制细胞增殖(对于EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3和DU-145细胞的IC50分别为2.2nM，3.8nM，5.9nM，6.9nM，9.2nM，70nM和818nM)，可增加细胞凋亡并减少血管生成。ABT-100具有广谱抗肿瘤活性。

  • GC60555 structure
    GC60555Acetyl phosphate(lithium potassium)
    CAS: 94249-01-1
    纯度: >99.50% / >97.00% / >98.00%

    乙酰磷酸锂钾（Acetyl phosphate(lithium potassium) ）是一种有机金属化合物，用作磷酰基供体，它常用于蛋白质磷酸化反应。

  • GC60558 structure
    GC60558Ac-FLTD-CMK
    CAS: 2376255-48-8
    纯度: >99.50%

    An inhibitor of caspase-1, -4, -5, and -11

  • GC60574 structure
    GC60574Allantoic acid
    CAS: 99-16-1
    纯度: >95.00%

    Allantoicacid是尿酸的降解产物，与嘌呤代谢有关。

  • GC60591 structure
    GC60591Apovincaminic acid hydrochloride salt
    CAS: 72296-47-0
    纯度: >98.00%

    Apovincaminicacidhydrochloridesalt是Vinpocetine(VP)的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminicacidhydrochloridesalt具有神经保护作用。

  • GC60603 structure
    GC60603Asperosaponin VI
    CAS: 39524-08-8
    纯度: >98.00%

    A triterpenoid saponin with diverse biological activities

  • GC60613 structure
    GC60613Azaleatin
    CAS: 529-51-1

    Azaleatin是一种从Rhododendron种中分离得到的O-甲基化黄酮醇。Azaleatin是二肽基肽酶-IV的抑制剂。Azaleatin可用于2型糖尿病和肥胖症的研究。

  • GC60633 structure
    GC60633Benzophenone
    CAS: 119-61-9
    纯度: >99.50%

    Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.

  • GC60640 structure
    GC60640Benzylideneacetone
    CAS: 122-57-6

    Benzylideneacetone是一种内源性代谢产物。

  • GC60672 structure
    GC60672Carveol
    CAS: 99-48-9

    A monoterpene alcohol with nematocidal activity

  • GC60720 structure
    GC60720Coenzyme FO
    CAS: 37333-48-5
    纯度: >99.00%

    CoenzymeFO是一种脱氮黄素发色团，在产甲烷途径中起着重要的氢化物受体/供体作用。

  • GC60728 structure
    GC60728Creosol
    CAS: 93-51-6
    纯度: >99.50%

    A phenolic pyrolysis product of plant biomass

  • GC60734 structure
    GC60734Cyclohexaneacetic acid
    CAS: 5292-21-7

    Cyclohexaneacetic acid is a flavouring ingredient.