Acetyl phosphate(lithium potassium) is an organometallic compound used as a phosphoryl donor and is commonly used in protein phosphorylation reactions[1]. Acetyl phosphate (lithium potassium) is an endogenous compound involved in taurine and hypotaurine metabolism and pyruvate metabolism[2]. Acetyl phosphate (lithium potassium) is produced from sulfoacetaldehyde and converted to acetyl-CoA and acetate by phosphate acetyltransferase and acetate kinase, respectively[3]. Acetyl phosphate (lithium potassium) is also an intermediate in pyruvate metabolism[4]. Acetyl phosphate (lithium potassium) is suitable as an acetyl phosphate source, which is useful for reducing the formation of inorganic monophosphate byproducts by replacing inorganic oligophosphates in phosphatase-catalyzed transphosphorylation[5].
References:
[1]Li D Y, Han J T, Zhang M Y, et al. The two-component system RstA/RstB regulates expression of multiple efflux pumps and influences anaerobic nitrate respiration in Pseudomonas fluorescens[J]. Msystems, 2021, 6(6): e00911-21.
[2]Nciri R, Desmoulin F, Allagui M S, et al. Neuroprotective effects of chronic exposure of SH-SY5Y to low lithium concentration involve glycolysis stimulation, extracellular pyruvate accumulation and resistance to oxidative stress[J]. International Journal of Neuropsychopharmacology, 2013, 16(2): 365-376.
[3]Ruff J, Denger K, Cook A M. Sulphoacetaldehyde acetyltransferase yields acetyl phosphate: purification from Alcaligenes defragrans and gene clusters in taurine degradation[J]. Biochemical Journal, 2003, 369(2): 275-285.
[4]Fan T W M, Yuan P, Lane A N, et al. Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions[J]. Metabolomics, 2010, 6: 165-179.
[5]Johnson D C, Widlanski T S. Overview of the synthesis of nucleoside phosphates and polyphosphates[J]. Current protocols in nucleic acid chemistry, 2003, 15(1): 13.1. 1-13.1. 31.
乙酰磷酸锂钾（Acetyl phosphate(lithium potassium) ）是一种有机金属化合物，用作磷酰基供体，它常用于蛋白质磷酸化反应[1]。Acetyl phosphate(lithium potassium)是一种内源性化合物，参与牛磺酸和亚牛磺酸代谢以及丙酮酸代谢[2]。Acetyl phosphate(lithium potassium)由磺基乙醛产生，分别通过磷酸乙酰转移酶和乙酸激酶转化为乙酰辅酶A和乙酸[3]。Acetyl phosphate(lithium potassium)也是丙酮酸代谢的中间体[4]。Acetyl phosphate(lithium potassium)适合作为乙酰磷酸源，它适用于通过替代磷酸酶催化的转磷酸化中的无机低聚磷酸盐来减少无机单磷酸盐副产物的形成[5]。