GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC60474 structure
    GC604742-Hydroxy atorvastatin lactone
    CAS: 163217-74-1

    2-Hydroxyatorvastatinlactone是Atorvastatin的代谢产物。2-Hydroxyatorvastatinlactone是一种口服活性HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。

  • GC60475 structure
    GC604752-Hydroxy-4-methylbenzaldehyde
    CAS: 698-27-1

    2-Hydroxy-4-methylbenzaldehyde是一种内源性代谢产物。

  • GC60476 structure
    GC604762-hydroxymethyl benzoic acid
    CAS: 612-20-4

    2-hydroxymethylbenzoicacid是一种内源性代谢产物。

  • GC60477 structure
    GC604772-Methylbenzaldehyde
    CAS: 529-20-4

    2-Methylbenzaldehyde是一种内源性代谢产物。

  • GC60478 structure
    GC604782-Methylbenzoxazole
    CAS: 95-21-6
    纯度: >99.50%

    2-Methylbenzoxazole是一种内源性代谢产物。

  • GC60479 structure
    GC604792-Methylcitric acid
    CAS: 6061-96-7
    纯度: >97.00%

    An endogenous tricarboxylic acid

  • GC60480 structure
    GC604802-Methylcitric acid trisodium
    CAS: 117041-96-0
    纯度: >96.00%

    An endogenous tricarboxylic acid

  • GC60481 structure
    GC604812-Methylvaleric acid
    CAS: 97-61-0
    纯度: >98.00%

    2-Methylpentanoic acid (2-Methylvaleric acid, Methylpropylacetic acid) is a short-chain fatty acid that exists in various foods including cheeses, cherimoya, lamb and mutton, and so on. 2-Methylpentanoic acid is a flavor compound used for food-flavor ingredient, fragrances.

  • GC60483 structure
    GC604832-Phenylacetamide
    CAS: 103-81-1
    纯度: >99.00%

    A metabolite of L-phenylalanine

  • GC60485 structure
    GC604852-Phenylglycine
    CAS: 2835-06-5
    纯度: >97.00%

    2-Phenylglycine(DL-α-Phenylglycine)是在W2至W4泌乳期间母乳中的代谢产物。

  • GC60486 structure
    GC604862-Piperidone
    CAS: 675-20-7
    纯度: >97.00%

    2-Piperidone是一种内源性代谢产物。

  • GC60487 structure
    GC604872-Thiophenecarboxaldehyde
    CAS: 1998-3-3
    纯度: >99.50%

    2-Thiophenecarboxaldehyde是一种内源性代谢产物。

  • GC60488 structure
    GC604883-(3-Hydroxyphenyl)propionic acid
    CAS: 621-54-5
    纯度: >98.00% / >99.00%

    3-(3-Hydroxyphenyl)propionic acid (m-Hydroxyphenylpropionic acid, 3-Hydroxyhydrocinnamic acid) is one of the major metabolites of ingested caffeic acid and of the phenolic degradation products of proanthocyanidins by the microflora in the colon.

  • GC60491 structure
    GC604913,3-Dimethylglutaric acid
    CAS: 4839-46-7

    3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) is a compound that has occasionally found in human urine.

  • GC60493 structure
    GC604933',4'-Dihydroxyacetophenone
    CAS: 1197-09-7
    纯度: >99.50%

    3',4'-Dihydroxyacetophenone(3,4-DHAP)可从PiceaSchrenkiana中分离得到，能抑制酪氨酸酶，其IC50值为10μM。3',4'-Dihydroxyacetophenone(3,4-DHAP)是一种血管活性物质和抗氧化剂。

  • GC60497 structure
    GC604973,5-Dihydroxyacetophenone
    CAS: 51863-60-6

    3,5-Dihydroxyacetophenone是一种内源性代谢产物。

  • GC60500 structure
    GC605003'-Hydroxy Repaglinide D5
    CAS: 1352792-15-4
    纯度: >98.00%

    3'-HydroxyRepaglinideD5是3'-HydroxyRepaglinide的氘代物。3'-HydroxyRepaglinide是Repaglinide的主要CYP2C8代谢产物。

  • GC60501 structure
    GC605013-Hydroxy-4-aminopyridine
    CAS: 52334-53-9
    纯度: >98.50%

    3-Hydroxy-4-aminopyridine是一种内源性代谢产物。

  • GC60502 structure
    GC605023-Hydroxybutyric acid sodium
    CAS: 150-83-4
    纯度: >98.00%

    3-Hydroxybutyricacidsodium(β-Hydroxybutyricacidsodium)是一种在I型糖尿病中升高的代谢物。3-Hydroxybutyricacidsodium可以调节膜脂的性质。

  • GC60505 structure
    GC605053-O-Methyldopa
    CAS: 300-48-1
    纯度: >98.00%

    3-O-Methyldopa(3-Methoxy-L-tyrosine)是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。

  • GC60506 structure
    GC605063-O-Methyldopa D3
    CAS: 586954-09-8
    纯度: >99.00%

    3-O-MethyldopaD3(3-Methoxy-L-tyrosineD3)是3-O-Methyldopa的氘代物。3-O-Methyldopa是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。

  • GC60510 structure
    GC605104,4-Dimethoxy-2-butanone
    CAS: 5436-21-5

    4,4-Dimethoxy-2-butanone是一种内源性代谢产物。

  • GC60512 structure
    GC605124-Carboxypyrazole
    CAS: 37718-11-9
    纯度: >99.50%

    4-Carboxypyrazole是一种内源性代谢产物。

  • GC60514 structure
    GC605144-Ethoxyphenol
    CAS: 622-62-8
    纯度: >99.50%

    4-Ethoxyphenol是一种内源性代谢产物。