GLPBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC60371 structure
    GC60371Trimethylammonium chloride
    CAS: 593-81-7
    纯度: >98.00%

    Trimethylammonium chloride 是一种内源性代谢产物。

  • GC60377 structure
    GC60377Urolithin C
    CAS: 165393-06-6
    纯度: >97.00%

    UrolithinC，是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂，可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。

  • GC60383 structure
    GC60383Vomifoliol
    CAS: 23526-45-6

    Vomifoliol是一种与脱落酸(ABA)有关的化合物，具有修饰的2,4-戊二烯侧链，其活性与ABA的活性相当。Vomifoliol表现出抗乙酰胆碱酯酶(antiacetylcholinesterase)活性和中等抗利什曼虫(antileishmanial)活性。

  • GC60399 structure
    GC60399(E)-10-Hydroxynortriptyline
    CAS: 47132-16-1
    纯度: >99.50%

    An active metabolite of amitriptyline and nortriptyline

  • GC60404 structure
    GC60404(Ethoxymethyl)benzene
    CAS: 539-30-0
    纯度: >95.00%

    (Ethoxymethyl)benzene是一种内源性代谢产物。

  • GC60410 structure
    GC60410(Rac)-3′-Hydroxy simvastatin
    CAS: 126313-98-2

    (Rac)-3′-Hydroxysimvastatin是一种Simvastatin代谢物。Simvastatin是一种竞争性的HMG-CoA还原酶抑制剂，Ki值为0.2nM。

  • GC60419 structure
    GC60419(S)-O-Desmethyl Venlafaxine N-Oxide
    CAS: 1021934-03-1

    (S)-O-DesmethylVenlafaxineN-Oxide是(S)-O-DesmethylVenlafaxine的N-氧化物。O-DesmethylVenlafaxine是Venlafaxine的活性代谢产物。Venlafaxine是5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)类的抗抑郁剂。

  • GC60427 structure
    GC60427(Z)-10-Hydroxynortriptyline
    CAS: 47132-19-4
    纯度: >99.00%

    An active metabolite of amitriptyline and nortriptyline

  • GC60429 structure
    GC60429[(3R)-3-Hydroxydodecanoyl]-L-carnitine
    CAS: 1469900-99-9

    [(3R)-3-Hydroxydodecanoyl]-L-carnitine是一种内源性代谢产物。

  • GC60433 structure
    GC604331,3-Dimethyluracil
    CAS: 874-14-6
    纯度: >99.50%

    1,3-Dimethyluracil (N,N'-dimethyluracil) is a methyl derivative of uric acid, found occasionally in human urine.

  • GC60435 structure
    GC604351,4-Dimethoxybenzene
    CAS: 150-78-7

    1,4-二甲氧基苯是一种有机化合物，是二甲氧基苯的三种异构体之一。它是一种白色固体，带有强烈甜美的花香，由多种植物产生，主要用于香水和肥皂。是合成有机化合物的中间体，也可用作黑白胶片的显影剂。

  • GC60443 structure
    GC6044312-Ketodeoxycholic acid
    CAS: 5130-29-0
    纯度: >98.00%

    12-Ketodeoxycholic acid是次级胆汁酸脱氧胆酸（deoxycholic acid）的代谢产物。

  • GC60445 structure
    GC604451-Dodecanol
    CAS: 112-53-8
    纯度: >99.00%

    1-dodecanol 是一种天然产物，存在于薇甘菊和金丝桃等，是一种内源性代谢产物

  • GC60448 structure
    GC604481-Hydroxypyrene
    CAS: 5315-79-7
    纯度: >98.50%

    1-羟基芘 (1-Hydroxypyrene，1 - OHP) 是一种人体代谢产物，也是一种广泛使用的生物标志物，可作为暴露于多环芳烃 (PAH) 的指标

  • GC60449 structure
    GC604491-Methylxanthine
    CAS: 6136-37-4
    纯度: >98.00%

    1-甲基黄嘌呤属于称为黄嘌呤的有机化合物类别。这些是嘌呤衍生物，在嘌呤部分的碳 2 和 6 处有一个酮基共轭。它也是由嘌呤核苷磷酸化酶从黄苷产生的。可增强肿瘤细胞的放射敏感性

  • GC60452 structure
    GC604522(5H)-Furanone
    CAS: 497-23-4
    纯度: >99.00%

    2(5H)-Furanone是一种内源性代谢产物。

  • GC60457 structure
    GC604572,3,5-Trimethylpyrazine
    CAS: 14667-55-1
    纯度: >99.50%

    2,3,5-Trimethylpyrazine是一种内源性代谢产物。

  • GC60458 structure
    GC604582,3-Butanediol
    CAS: 513-85-9
    纯度: >98.00%

    2,3-Butanediol (Dimethylene glycol, 2,3-Dihydroxybutane, Butan-2,3-diol, 2,3-Butylene glycol) is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on.

  • GC60462 structure
    GC604622',4'-Dimethylacetophenone
    CAS: 89-74-7

    2',4'-Dimethylacetophenone是一种内源性代谢产物。

  • GC60463 structure
    GC604632,4-Di-tert-butylphenol
    CAS: 96-76-4
    纯度: >99.50%

    2,4-Di-tert-butylphenol是一种内源性代谢产物。

  • GC60469 structure
    GC604692-Acetyl-3-ethylpyrazine
    CAS: 32974-92-8

    2-Acetyl-3-ethylpyrazine是一种内源性代谢产物。

  • GC60470 structure
    GC604702-Amino-5-phenylpyridine
    CAS: 33421-40-8

    2-Amino-5-phenylpyridine是一种诱变的杂环芳族胺，是通过蛋白质中的苯丙氨酸热解形成的。2-Amino-5-phenylpyridine存在于烤沙丁鱼等食品中，并且具有潜在的致癌性。

  • GC60471 structure
    GC604712-Benzylsuccinic acid
    CAS: 884-33-3
    纯度: >98.00%

    DL-Benzylsuccinic acid (2-benzylbutanedioic acid, Benzylsuccinic acid) is a bacterial xenobiotic metabolite.

  • GC60472 structure
    GC604722-Ethylpyrazine
    CAS: 13925-00-3
    纯度: >99.50%

    2-Ethylpyrazine是一种内源性代谢产物。