trans-10-hydroxy Nortriptyline is an active metabolite of the tricyclic antidepressants amitriptyline and nortriptyline .1,2 It is formed from amitriptyline and nortriptyline by the cytochrome P450 (CYP) isoform CYP2D6.1 trans-10-hydroxy Nortriptyline inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively).2
1.Coutts, R.T., Bach, M.V., and Baker, G.B.Metabolism of amitriptyline with CYP2D6 expressed in a human cell lineXenobiotica27(1)33-47(1997) 2.Bertilsson, l., Mellstr?m, B., and Sj?qvist, F.Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptylineLife Sci.25(15)1285-1292(1979)