GlpBio

NNMTi

目录号: GC50601纯度: >99.50%同义词: 5-氨基-1-甲基喹啉-1-鎓碘化物
NNMTi 是一种有效的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂 (IC50=1.2 μM)，可选择性结合 NNMT 底物结合位点残基。
NNMTi
Cas No.: 42464-96-0
规格价格库存数量操作
5 mg¥420.00现货
1
10 mg¥602.00现货
1
25 mg¥1,208.00现货
1
50 mg¥2,083.00现货
1
100 mg¥2,923.00现货
1
10mM (in 1mL DMSO)¥462.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.

Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID:30753815 |Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID:28548833

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
42464-96-0
同义词
5-氨基-1-甲基喹啉-1-鎓碘化物
SMILES
[I-].C[N+]1=CC=CC2=C(N)C=CC=C12
分子式
C10H11IN2
分子量
286.11 g/mol
溶解性
DMSO : 20.83 mg/mL (72.80 mM; ultrasonic and warming and heat to 60°C); H<sub>2</sub>O : 2.27 mg/mL (7.93 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol