Signaling Pathways

PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.

TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM).

TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).

AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2.

Etomidate-d5 is intended for use as an internal standard for the quantification of etomidate by GC- or LC-MS.

77PD-Q is a p-phenylenediamine quinone (PPD-Q) and an oxidized derivative of the antiozonant 77PD.

ABBV-CLS-484 is a dual inhibitor of protein tyrosine phosphatase 1N (PTP1N) and PTP2N (IC50s = 2.5 and 1.8 nM, respectively).

Ochratoxin B-13C20 (OTB-13C20) is intended for use as an internal standard for the quantification of ochratoxin B by GC- or LC-MS.

ENPP3 inhibitor 5J is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) and ENPP3 (IC50s = 0.59 and 0.62 µM, respectively, for the human enzymes).

GSK205 is an inhibitor of transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1; IC50s = 4.19 and 5.56 µM, respectively, for the rat channels).

18-hydroxy Oleoyl leucine-d7 is intended for use as an internal standard for the quantification of 18-hydroxy oleoyl leucine by GC- or LC-MS.

h-e5'NT Inhibitor 5C is an inhibitor of ecto-5'-nucleotidase, also known as CD73 (IC50s = 0.37 and 1.66 µM for the human and rat enzymes, respectively).

PD-1/PD-L1 inhibitor N11 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1; IC50 = 6.3 nM).

NVS-STG2 is an agonist of stimulator of interferon genes (STING).

Ochratoxin C-13C20 (OTC-13C20) is intended for use as an internal standard for the quantification of ochratoxin C by GC- or LC-MS.

BODIPY-Linoleate is a fluorescently tagged derivative of linoleic acid .

DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC50 = 0.0034 µM).

FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.

LB244 is an irreversible STING antagonist.

AMG PERK 44 is a protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 6 nM).

Cholic acid 3-sulfate is a metabolite of the primary bile acid cholic acid .

CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).

DB2313 is an inhibitor of the transcription factor PU.