viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).1 It induces ferroptosis in glutathione peroxidase 4 (Gpx4) knockout Pfa1 mouse embryonic fibroblasts expressing human or mouse FSP1, an effect that can be reversed by the ferroptosis inhibitor liproxstatin-1.
References:
[1].Nakamura, T., Mishima, E., Yamada, N., et al.Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulationNat. Struct. Mol. Biol.30(11)1806-1815(2023).
















