Cholic acid 3-sulfate is a metabolite of the primary bile acid cholic acid .[1],[2] Plasma levels of cholic acid 3-sulfate are increased in patients with intrahepatic cholestasis and mutations in the gene encoding the bile salt export pump (BSEP), ABCB11.[3]
References:
[1].Alnouti, Y.Bile acid sulfation: A pathway of bile acid elimination and detoxificationToxicol. Sci.108(2)225-246(2009).
[2].Goto, J., Kato, H., Saruta, Y., et al.Studies on steroids. CLXX. Separation and determination of bile acid 3-sulfates in human bile by high-performance liquid chromatographyJ. Chromatogr.226(1)13-24(1981).
[3].Liu, T., Wang, R.-X., Han, J., et al.Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlationsLiver Int.38(9)1676-1685(2018).